HAO1 Antibody

• Catalog number
  bs-8602R
• Price
  Please ask
• Size
  0.1ml

• Long name
  HAO1 Primary Polyclonal Antibody
• Also known as
  HAO1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  HAO1
• Specificity
  This is a highly specific antibody against HAO1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GOX/HAO1
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  GOX is a 370 amino acid protein that is expressed in liver and pancreas. HAO1 is localized to peroxisomes and aids in organic acid metabolism via 2-hydroxyacid oxidase activity. 2-hydroxyacid oxidases, such as HAO1, are enzymes that require a flavin cofactor to oxidize 2-hydroxyacids to 2-ketoacids while reducing oxygen to hydrogen peroxide. HAO1 prefenentially oxidizes the substrate glycolate and also oxidizes other substrates, including 2-hydroxy fatty acids as well as L-?hydroxy acids of moderately short chain lengths. The oxidation of glycolate yields glyoxylate which is utilized for peroxisomal synthesis of glycine. HAO1 is also able to convert glyoxylate to oxalate. HAO1 is thought to play a role in the pathophysiology of hyperoxaluria type 1, which is caused by defects in AGXT, a peroxisomal enzyme, leading to accumulation of glyoxylate. Hyperoxaluria type 1 is characterized by an accumulation of oxalate that is thought to lead to precipitates of calcium oxalate in kidneys which can be fatal.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Glycolate oxidase; GOX; GOX1; HAO1; HAOX1; HAOX1_HUMAN; Hydroxyacid oxidase 1; MGC142225; MGC142227; OTTHUMP00000030231; S 2 hydroxy acid oxidase.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HAO1  
• Gene symbol
  HAO1
• Short name
  Anti-HAO1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  HAO1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4809
• Gene
  HAO1
• Long gene name
  hydroxyacid oxidase 1
• Synonyms gene
  • GOX1
• Synonyms gene name
  • hydroxyacid oxidase (glycolate oxidase) 1
• Synonyms
  • GOX
• Synonyms name
  • glycolate oxidase 1
• GenBank acession
  • AL021879
• Locus
  20p12.3
• Discovery year
  1999-09-09
• Entrez gene record
  54363
• Pubmed identfication
  • 9891009
• VEGA ID
  OTTHUMG00000031841

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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