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Stock availabilitIn Stock
In Stock
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CAS number
127243-85-0
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Description
PKA inhibitor
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Molecular weight
519,3 g/mol
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Primary research fields
Cell Signaling
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Other name
N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C20H22BrCl2N3O2S
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Origin
Synthetic
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Purity pourcentage
99% (TLC)
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Soluble in
Soluble in DMSO (25 mg/ml), methanol and 50% ethanol/water (20 mg/ml)
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Physical appearance
White to off-white solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
449241
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Scientific context
H89 Dihydrochloride is a potent and selective inhibitor of cAMP-dependent protein kinase (PKA). It has also been shown to inhibit CaM kinase II, casein kinase I and MYLK, as well as, Rsk-2, MSK1, Akt1, PKC µ, Rock-2, p70 S6 kinase α. H89 Dihydrochloride can induce apoptosis. It is cell permeable.
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Bibliography
1. Bouschet, T., (2003) J. Biol. Chem. 278(7): 4778–4785. 2. Findik D., Song Q., Hidaka H., & Lavin M. (1995) J. Cell. Biochem. 57(1): 12–21. 3. Davies S. P., Reddy H., Caivano M., & Cohen P. (2000) Biochem. J. 351(Pt 1): 95–105.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of H89 Dihydrochloride (SIH-452), a PKA inhibitor. CAS #: 127243-85-0. Molecular Formula: C20H22BrCl2N3O2S. Molecular Weight: 519.3 g/mol. Chemical structure of H89 Dihydrochloride, a PKA inhibitor (SIH-452). CAS # 127243-85-0. Molecular Formula: C20H22BrCl2N3O2S.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
