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Stock availabilitIn Stock
In Stock
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CAS number
220904-83-6
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Description
c-Raf1 kinase inhibitor
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Molecular weight
520,9 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C15H8Br2INO2
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Origin
Synthetic
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Purity pourcentage
≥98% (TLC)
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Soluble in
Soluble to 1 mM in ethanol and to 100 mM in DMSO
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Physical appearance
Yellow to orange solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
5924208
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Scientific context
GW5074 is a potent and selective c-Raf1 kinase inhibitor. GW5074 shows ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW5074 has been shown to block low potassium induced cell death, as well as, prevent neurodegeneration. GW5074 is cell-permeable.
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Bibliography
1. Chin P.C., et al. (2004) J. Neurochem. 90(3): 595–608. 2. Lackey K., et al. (2000). Bioorganic Med. Chem. Ltr. 10(3): 223–226. 3. Chang M.S., (2005). Cell Signal. 17(3): 299–310.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of GW5074 (SIH-451), a c-Raf1 kinase inhibitor. CAS #: 220904-83-6. Molecular Formula: C15H8Br2INO2. Molecular Weight: 520.9 g/mol. Chemical structure of GW5074 , a c-Raf1 kinase inhibitor (SIH-451). CAS # 220904-83-6. Molecular Formula: C15H8Br2INO2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
