GSK-J1 (Free acid)

Alternative_name

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
Description

GSK-J1 is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available (Cat. Nos. 2259 & 2762).
CAS Number

1373422-53-7
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₂H₂₃N₅O₂
Molecular Weight

398.45
Cell Permeable

Y
Purity

≥98% by TLC
Solubilities

DMSO (~ 20 mg/ml)
Handling

Protect from light and moisture
Tag Line

A potent histone demethylase JMJD3/UTX inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
MDL Number

MFCD22683851
PubChem CID

56963315
PubChem CID Link
SMILES

C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O
InChi

InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26)
InChi Key

AVZCPICCWKMZDT-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes