NGF beta Recombinant Protein

• Catalog number
  40-495
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• About recombinant protein
  Beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Beta-NGF is a potent neurotrophic factor that signals through its receptor beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human beta-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity.
• Other name of the recombinant
  NGFB, HSAN5, Beta-NGF, NGFB, Beta-nerve growth factor
• Recombinant in
  E. coli
• SEQUENCE
  SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
• Activity
  Biological activity was determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is < 1.0 ng/mL, corresponding to a specific activity of > 1 x 106 units/mg.
• Keep at
  The lyophilized NGF beta recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted NGF beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing NGF beta recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  70995319
• Accession nr
  NP_002497.2
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  4803
• Gene name
  nerve growth factor (beta polypeptide)
• Source
  Homo sapiens
• Uniprot
  P01138
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  NGF   beta   Protein  
• Gene symbol
  NGF
• Short name
  NGF beta Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  nerve growth factor (beta polypeptide) b Rec. Protein
• Alternative technique
  rec
• Alternative to gene target
  nerve growth factor (beta polypeptide), Beta-NGF and HSAN5 and NGFB, NGF and IDBG-101347 and ENSG00000134259 and 4803, growth factor activity, Extracellular, Ngf and IDBG-180362 and ENSMUSG00000027859 and 18049, NGF and IDBG-648895 and ENSBTAG00000007446 and 281350

Gene info

• Identity
  HGNC:7808
• Gene
  NGF
• Long gene name
  nerve growth factor
• Synonyms gene
  • NGFB
• Synonyms gene name
  • nerve growth factor (beta polypeptide)
• Locus
  1p13.2
• Discovery year
  2001-06-22
• Entrez gene record
  4803
• RefSeq identity
  • NM_002506
• Classification
  • Neurotrophins
• VEGA ID
  OTTHUMG00000011880
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LRG_260

Gene info

• Identity
  HGNC:53922
• Gene
  NGF-AS1
• Long gene name
  NGF antisense RNA 1
• Synonyms
  • RP4-663N10.1
• Locus
  1p13.2
• Discovery year
  2018-06-08
• Pubmed identfication
  • 29855537
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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