Gremlin-1 Recombinant Protein

• Catalog number
  40-594
• Price
  Please ask
• Size
  0.01 mg, 0.05 mg

• About recombinant protein
  Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.
• Other name of the recombinant
  DRM, HMPS, PIG2, CRAC1, DAND2, IHG-2, GREMLIN, CKTSF1B1, DRM, Gremlin-1, Cell proliferation-inducing gene 2 protein
• Recombinant in
  CHO cells
• SEQUENCE
  KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
• Activity
  Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 μg/mL.
• Keep at
  The lyophilized Gremlin-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Gremlin-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Gremlin-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  300797307
• Accession nr
  NP_001178251.1
• Pureity
  Greater than 90% by SDS-PAGE gel and HPLC analyses.
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  26585
• Gene name
  gremlin 1, DAN family BMP antagonist
• Source
  Homo sapiens
• Uniprot
  O60565
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Gremlin-1   Protein  
• Gene symbol
  GREM1
• Short name
  Gremlin-1 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Gremlin-1 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:55411
• Gene
  GREM1-AS1
• Long gene name
  GREM1 antisense RNA 1
• Locus
  15q13.3
• Discovery year
  2021-01-06
• Entrez gene record
  100131315
• RefSeq identity
  • NR_109767
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:2001
• Gene
  GREM1
• Long gene name
  gremlin 1, DAN family BMP antagonist
• Synonyms gene
  • CKTSF1B1
  • CRAC1
• Synonyms gene name
  • cysteine knot superfamily 1, BMP antagonist 1
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
  • gremlin 1
  • colorectal adenoma and carcinoma 1
• Synonyms
  • DRM
  • gremlin
  • DAND2
  • HMPS
• Synonyms name
  • hereditary mixed polyposis syndrome
  • down-regulated in mos-transformed cells
• Locus
  15q13.3
• Discovery year
  1999-12-02
• Entrez gene record
  26585
• Pubmed identfication
  • 9660951
  • 10026205
  • 22561515
  • 27385727
• RefSeq identity
  • NM_013372
• Classification
  • DAN family
• VEGA ID
  OTTHUMG00000129319
• Locus Specific Databases
  • LRG_1365

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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