gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Mouse Monoclonal Antibody

• Catalog number
  MBS438600
• Price
  Please ask
• Size
  5x0.1 mg (Without BSA & Azide at 1mg/mL)

• Products_type
  Antibody
• Products_short_name
  [gp100 / Melanosome / PMEL17 / SILV]
• Products_name_syn
  [95kDa melanocyte-specific secreted glycoprotein, M-beta, Melanocyte lineage specific antigen GP100, Melanocyte protein Pmel 17, Melanoma associated ME20 antigen, Melanosomal matrix protein17, p100, p26, PMEL17, Premelanosome protein, Secreted melanoma-associated ME20 antigen, SILV, Silver homolog]
• Other_names
  [melanocyte protein PMEL isoform 2; Melanocyte protein PMEL; melanocyte protein PMEL; premelanosome protein; ME20-M; ME20M]
• Products_gene_name
  [SILV]
• Other_gene_names
  [PMEL; PMEL; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E; D12S53E; PMEL17; SILV; ME20M; ME20-S; ME20S]
• Clonality
  Monoclonal
• Clone
  [PMEL/783]
• Reactivity
  Human. Others not tested
• Specificity
  Cytotoxic T lymphocytes (CTLs) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  gp100   Melanosome   PMEL17   SILV   Melanoma   Monoclonal  
• Gene symbol
  PMEL
• Short name
  gp100 / Melanosome / PMEL17 / SILV (Melanoma ) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG1, kappa
• Species
  Mouse, Mouses
• Alternative name
  gp100 / Melanosome / PMEL17 / SILV (Melanoma detection labelled) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine

Gene info

• Identity
  HGNC:10880
• Gene
  PMEL
• Long gene name
  premelanosome protein
• Synonyms gene
  • SIL
  • SILV
• Synonyms gene name
  • silver (mouse homolog) like
  • silver homolog (mouse)
• Synonyms
  • D12S53E
  • SI
  • Pmel17
  • gp100
  • HMB-45
  • ME20
• GenBank acession
  • AK092881
• Locus
  12q13.2
• Discovery year
  1997-06-24
• Entrez gene record
  6490
• Pubmed identfication
  • 8739560
• RefSeq identity
  • NM_006928
• VEGA ID
  OTTHUMG00000170573

MeSH Data

• Name
  Mammary Neoplasms, Experimental
• Concept
  Scope note: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
• Tree numbers
  • C04.588.531.500
  • C04.619.590
  • E05.598.500.496.843
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, secondary, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, chemistry, psychology, urine, virology, history, blood supply, classification, economics, embryology, genetics, nursing, radiotherapy, prevention & control, pathology, ultrastructure, metabolism, complications, surgery

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