Goat anti Human Factor XII, Primary Antibodies

• Catalog number
  GAHu-FXII
• Price
  Please ask
• Size
  1ml

• Host Source
  Goat
• Clone Name
  Polyclonal
• Product Category
  Cardiovascular
• Species Reactivity
  Human
• Application
  Immunoprecipitation
• Immunogen
  Factor XII (Hageman factor) is a single chain glycoprotein (MW 80,000). It is a serine protease zymogen. FXII is converted to an active enzyme by damage to vascular endothelium. In vitro activation is caused by glass or kaolin. Surface binding promotes activation by kallikrein. FXIIa activates prekallikrein and FXI. Kallikrein activates more FXII. Fragments of FXIIa activate FVII to FVIIa, and plasminogen to plasmin. The complement system is also activated by FXIIa. A link between fibrin clot and the subendothelium is formed by FXIIa crosslinking with fibrin, alpha-2 plasmin inhibitor, fibronectin and Van Willebrand factor. Purified plasma FXII is used as immunogen._x000B__x000B_FreundÍs complete adjuvant is used in the first step of the immunization procedure.
• Purification Method
  NA
• Shipping Conditions
  NA
• Storage conditions
  Goat anti Human Factor XII, Primary Antibodies philized antiserum is shipped at ambient temperature and may be stored at +4ÁC; prolonged storage at or below -20ÁC. Reconstitute the lyophilized antiserum by adding 1 ml sterile distilled water. Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at +4ÁC, not refrozen, and preferably used the same day. Lyophilized at +4Á C--at least 10 years. Reconstituted at or below -20Á C--3-5 years. Reconstituted at +4Á C--7 days
• Datasheet link
  NA
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
• Latin name
  Capra aegagrus hircus
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

• Gene target
  Factor   XII   Primary   Antibodies  
• Gene symbol
  SIGLEC12
• Short name
  Goat anti Factor XII, Primary Antibodies
• Technique
  anti human, anti, Goat, antibody to, anti human antibodies, goats
• Host
  Goat, The goat polyclonal antibodies are directed against human genes or rabbit or mouse IgGs (H +L) chain primary antibodies and conjugated for detection. It are very good secondary antibodies that are affinity purified and have a good affinity themselves too. Often KLH is coupled to the antigen so anti KLH can be present in the vial.
• Isotype
  NA
• Species
  Human, Goats, Humans
• Alternative name
  caprine antibody to H. sapiens Factor XII, captor Antibodies
• Alternative technique
  antibodies, caprine

Gene info

• Identity
  HGNC:15482
• Gene
  SIGLEC12
• Long gene name
  sialic acid binding Ig like lectin 12
• Synonyms gene
  • SIGLECL1
• Synonyms gene name
  • SIGLEC-like 1
  • sialic acid binding Ig-like lectin 12
  • sialic acid binding Ig-like lectin 12 (gene/pseudogene)
  • sialic acid binding Ig like lectin 12 (gene/pseudogene)
• Synonyms
  • SLG
  • S2V
  • Siglec-XII
  • Siglec-12
  • Siglec-L1
• GenBank acession
  • AF282256
• Locus
  19q13.41
• Discovery year
  2001-08-28
• Entrez gene record
  89858
• Pubmed identfication
  • 11409877
  • 11328818
  • 21555517
• RefSeq identity
  • NM_053003
• Classification
  • C2-set domain containing
  • I-set domain containing
  • Sialic acid binding Ig like lectins
  • V-set domain containing
• VEGA ID
  OTTHUMG00000165524

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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