GSK-690693

• Catalog number
  2272-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)­-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[­4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
• Description
  An ATP-competitive pan-Akt kinase inhibitor. Inhibits Akt kinase isoforms 1, 2, 3 with IC₅₀ values of 2, 13, and 9 nM, respectively. Inhibited proliferation and induced apoptosis in a subset of tumor cells with potency consistent with intracellular inhibition of Akt kinase activity.
• CAS Number
  937174-76-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₇N₇O₃
• Molecular Weight
  425.48
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~20 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A pan-Akt kinase inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD14105605
• PubChem CID
  16725726
• PubChem CID Link
• SMILES
  CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
• InChi
  InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
• InChi Key
  KGPGFQWBCSZGEL-ZDUSSCGKSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GSK-690693  
• Short name
  GSK-690693
• Alternative name
  GSK-690693

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