GNAS (559CT 16.1.3) Monoclonal Antibody
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Catalog number
bsm-51190M
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Price
Please ask
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Size
0.1ml
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Long name
GNAS (559CT 16.1.3) Monoclonal Antibody
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Also known as
GNAS (559CT 16.1.3) Monoclonal Antibody
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Category
Primary Antibodies
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Conjugation
Unconjugated
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Target Antigen
GNAS
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Specificity
This is a highly specific antibody against GNAS.
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Modification s
None
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Modification site s
Unmodified antibody
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Clonality
Monoclonal
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Clone number
559CT 16.1.3
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Source
This GNAS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from human GNAS.
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Swiss Prot
Q5FWY2
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Tested Applications
WB
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Recommended dilutions
WB(1:300)
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Cross reactivity
Mouse
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigen
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
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Purification method
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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French translation
anticorps
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Gene target
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Gene symbol
GNAS-AS1, GNAS
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Short name
Anti-GNAS
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Technique
Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
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Host
Mouse (Mus musculus)
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Isotype
IgM
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Alternative name
GNAS (559CT 16.1.3) Monoclonal Antibody
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
GNAS antisense RNA 1
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Synonyms gene
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Synonyms gene name
- GNAS antisense RNA (non-protein coding)
- GNAS antisense RNA 1 (non-protein coding)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2008-06-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene name
GNAS complex locus
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Synonyms gene
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Synonyms gene name
- guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1990-06-29
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Entrez gene record
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RefSeq identity
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Classification
- G protein subunits alpha, group s
- Granins
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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