Glucagon Receptor Antibody, ALEXA FLUOR 350

• Catalog number
  bs-3945R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  Glucagon Receptor Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-Glucagon Receptor PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Glucagon Receptor
• Specificity
  This is a highly specific antibody against Glucagon Receptor.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  26-70/477
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Glucagon Receptor
• Gene ID Number
  2642
• Swiss Prot
  P47871
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  GGR; GL-R; Glucagon receptor; GCGR
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• Description
  Glucagon gene and the glucagon like peptide or GLP1 gene are peptide hormones, produced by alpha cells of the pancreas to raise the concentration of glucose in the blood as opposite of insulin, which lowers the glucose. Anti human glucagon and glp1 antibodies are used to study diabetes. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• French translation
  anticorps

• Gene target
  Glucagon   Receptor  
• Gene symbol
  GLP2R, GCGR, GLP1R
• Short name
  Anti-Glucagon Receptor
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  Glucagon Receptor Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4325
• Gene
  GLP2R
• Long gene name
  glucagon like peptide 2 receptor
• Synonyms gene name
  • glucagon-like peptide 2 receptor
• GenBank acession
  • AF105367
• Locus
  17p13.1
• Discovery year
  1999-02-23
• Entrez gene record
  9340
• Pubmed identfication
  • 9990065
• Classification
  • Glucagon receptor family
• VEGA ID
  OTTHUMG00000130269

Gene info

• Identity
  HGNC:4192
• Gene
  GCGR
• Long gene name
  glucagon receptor
• Synonyms
  • GGR
• GenBank acession
  • U03469
  • L20316
• Locus
  17q25.3
• Discovery year
  1994-03-04
• Entrez gene record
  2642
• Pubmed identfication
  • 8020989
• RefSeq identity
  • NM_000160
• Classification
  • Glucagon receptor family
• VEGA ID
  OTTHUMG00000177914

Gene info

• Identity
  HGNC:4324
• Gene
  GLP1R
• Long gene name
  glucagon like peptide 1 receptor
• Synonyms gene name
  • glucagon-like peptide 1 receptor
• Synonyms
  • GLP-1R
• Locus
  6p21.2
• Discovery year
  1993-03-11
• Entrez gene record
  2740
• Classification
  • Glucagon receptor family
• VEGA ID
  OTTHUMG00000014638

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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