GIT1(Ser375) Antibody, ALEXA FLUOR 594

• Catalog number
  bs-5372R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  GIT1(Ser375) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-GIT1 Ser375 PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  GIT1 Ser375
• Specificity
  This is a highly specific antibody against GIT1 Ser375.
• Modification
  Phosphorylation
• Modification Site
  Ser375
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human GIT1 around the phosphorylation site of Ser375
• Gene ID Number
  28964
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  GIT1 phospho S375; p-GIT1 S375; ARF GAP GIT1; ARF GTPase activating protein GIT1; CAT 1; Cat1; Cool associated and tyrosine phosphorylated protein 1; G protein coupled receptor kinase interactor 1; GRK interacting protein 1.
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  GIT1   Ser375  
• Gene symbol
  GIT1
• Short name
  Anti-GIT1 Ser375
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  GIT1(Ser375) Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4272
• Gene
  GIT1
• Long gene name
  GIT ArfGAP 1
• Synonyms gene name
  • G protein-coupled receptor kinase interactor 1
  • G protein-coupled receptor kinase interacting ArfGAP 1
• GenBank acession
  • AF124490
• Locus
  17q11.2
• Discovery year
  2000-07-31
• Entrez gene record
  28964
• Pubmed identfication
  • 9826657
  • 10896954
• RefSeq identity
  • NM_014030
• Classification
  • ArfGAPs
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000132730

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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