Geldanamycin Hsp90 inhibitor

Geldanamycin Hsp90 inhibitor is available 2 times from Stressma labs

  • Origin
    Produced by fermentation
  • Soluble in
    Slightly soluble in methanol, chloroform or DMSO (10 mg/ml); insoluble in water
  • Other name
    (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
  • PubMed number
    Refer to PubMed
  • Description
    Hsp90 inhibitor
  • Warning information
    Non-hazardous
  • Representative figure legend
    Chemical structure of Geldanamycin (SIH-111), a Hsp90 inhibitor. CAS #: 30562-34-6. Molecular Formula: C29H40N2O9. Molecular Weight: 560.6 g/mol. Chemical structure of Geldanamycin, a Hsp90 inhibitor (SIH-111). CAS # 30562-34-6. Molecular Formula: C29H40N2O9.
  • Stock availabilitIn Stock
    In Stock
  • Purity pourcentage
    >95%
  • Tested applications
    To be tested
  • Primary research fields
    Cancer, Heat Shock
  • Total weight (kg)
    0.25
  • Product type
    Inhibitor
  • CAS number
    30562-34-6
  • Safety information
    Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects
  • Country of production
    Canada
  • Product category
    Small Molecules
  • Physical appearance
    Yellow Solid
  • Tested reactivity
    To be tested
  • PubChem number
    5288382
  • Bibliography
    1. Whitesell L., et al. (1994) Proc. Natl. Acad. Sci. USA 91:8324. 2. Neckers L. (2002) Trends Mol. Med. 8: S55. 3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478. 4. Chavany C., et al. 1996) Amer. Society Biochem Mol Bio. 9: 4974-4977. 5. Villa R., et al. (2003) Carcinogenesis. 24(5): 851-9. 6. Yamaki H., Iguchi-Ariga S.M., and Ariga H. (1989) J Antibiot (Tokyo). 42(4): 604-10.
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient

SIH-111A | Geldanamycin, Hsp90 inhibitorsize: 1 mg | 153.74 USD

  • Catalog number
    SIH-111A
  • Supplier
  • Price
    153.74 USD
  • Size
    1 mg
  • Molecular weight
    560,6 g/mol
  • Chemical formula
    C29H40N2O9
  • Scientific context
    Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at more.
  • Net weight (g)
    0.001
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Additional information

SIH-111B | Geldanamycin, Hsp90 inhibitorsize: 5 mg | 346.83 USD

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