Geldanamycin- Biotin,Hsp90 inhibitor

Research Area s

Cancer , Heat Shock
Category

Small Molecules
Product Type

Inhibitor
CAS No

30562-34-6
MolecularFormula

C55H87N7O17S
Molecular Weight

560.6
Purity

>98%
Solubility

Soluble in DMSO
Appearance

Purple Solid
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Properties

Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
Conjugation

Biotinylated
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.