Gefitinib for cell activation

Gefitinib for cell activation is available 2 times from Biovision labs

1589-5 | Gefitinib for cell activationsize: 5 mg | 185.98 USD

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1589-25 | Gefitinib for cell activationsize: 25 mg | 319.33 USD

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  • Description
    Gefitinib was found to be a potent inhibitor of EGFR kinase (Ki = 0.40 nM), but much weaker against ErbB-2 kinase (Ki = 870 nM) and ErbB-4 kinase (Ki = 1.1 µM). The IC₅₀ values for Gefitinib to inhibit HT-29 and LoVo cell growth were 23.6 - >100 µM and 7.3 - 48.5 µM, respectively, when the exposure times are from 18 hours to 3 days. The IC₅₀ values of Gefitinib to the breast cancer cell lines BT20, HCC1937, MDA-MB-231, BT474, and SKBR3 are 15.5±1.4, 8.4±1.5, 20.7±1.1, 0.25±0.05, 0.88±0.31 µM, respectively
  • Peptide sequence
    N/A
  • CAS number
    184475-35-2
  • Molecular weight
    446.9
  • Category
    Biochemicals
  • Molecular formula
    C₂₂H₂₄ClFN₄O₃
  • Physical appearance
    White to off-white solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥99% by HPLC
  • Reconstitute instructions
    DMSO (100 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    RT
  • Maximum time for storage
    24months
  • Storage instructions
    Protect from light and moisture
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    Gefitinib for activation
  • Technique
    activation
  • Alternative name
    Gefitinib to measure cellular activation
  • Tissue
    cell
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