Synaptic Ras-GAP 1 Antibody
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Catalog numberbs-11369R
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PricePlease ask
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Size0.1ml
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Long nameSynaptic Ras-GAP 1 Primary Polyclonal Antibody
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Also known asSynaptic Ras-GAP 1 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenSynGAP
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SpecificityThis is a highly specific antibody against SynGAP.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Synaptic Ras-GAP 1/SynGAP
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Gene ID number8831
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Tested ApplicationsIHC-P, IF(IHC-P)
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Recommended dilutionsIHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenThe PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. SynGAP (for synaptic GTPase activating protein), a novel synaptic RasGAP, is a brain-specific protein abundant in the cortex, hippocampus and olfactory bulb. SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins. It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors. SynGAP may be involved in the regulation of BDNF as well as Ras signaling. Its activity is inhibited by phosphorylation by CaMKII, which could result in the activation of the MAP kinase pathway.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesNeuronal RasGAP; p135 SynGAP; Ras GTPase activating protein SynGAP; Ras GTPase-activating protein SynGAP; RASA 1; RASA 5; RASA1; RASA5; SYGP1_HUMAN; Synaptic Ras GAP 1; Synaptic Ras GTPase activating protein 1; Synaptic Ras GTPase activating protein 1 homolog; Synaptic Ras GTPase activating protein 135kDa; synaptic Ras GTPase activating protein; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP 1; SYNGAP1; DKFZp761G1421; KIAA1938; MRD5; OTTHUMP00000064825; SYNGAP1.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolGAP43, ARHGAP32, ITGA3, RASA1
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Short nameAnti-SynGAP
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameSynaptic Ras-GAP 1 Polyclonal Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namegrowth associated protein 43
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Synonyms
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Synonyms name
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Locus
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Discovery year1990-07-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRho GTPase activating protein 32
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Synonyms
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GenBank acession
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Locus
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Discovery year2010-02-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Rho GTPase activating proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameintegrin subunit alpha 3
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody J143
- integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-02-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Integrin alpha subunits
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRAS p21 protein activator 1
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Synonyms gene
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Synonyms gene name
- RAS p21 protein activator (GTPase activating protein) 1
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Synonyms
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Synonyms name
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Locus
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Discovery year1989-06-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- SH2 domain containing
- C2 and RasGAP domain containing
- Pleckstrin homology domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data