GABRD GABA A Receptor delta Antibody Conjugated
GABRD GABA A Receptor delta Antibody Conjugated is available 8 times from Bioss primary conjugated antibodies labs
- CategoryConjugated Primary Antibodies
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenGABRD/GABA A Receptor delta
- SpecificityThis is a highly specific antibody against GABRD/GABA A Receptor delta.
- Modification siteNone
- ClonePolyclonal antibody
- Concentration1ug per 1ul
- Subcellular locationExtracellular
- SourceKLH conjugated synthetic peptide derived from human GABRD/GABA A Receptor delta
- CrossreactivityHuman, Mouse, Rat
- Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Antigen backgroundGAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R Alpha 1-6, GABAA R Beta 1-3, GABAA R Gamma1-3, GABAA R delta, GABAA R delta, GABAA R Gamma1 and GABAA R Gamma 2. The GABAB family is composed of GABAB R1 Alpha and GABAB R1 Beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
- Purification methodThis antibody was purified via Protein A.
- SynonymsGABAA receptor subunit delta; GABRD; Gamma aminobutyric acid GABA A receptor delta; Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor; Gamma-aminobutyric acid receptor subunit delta; GBRD_HUMAN; MGC45284.
- Alternative techniqueantibodies
bs-12077R-Biotin | GABRD/GABA A Receptor delta Antibody, Biotin Conjugatedsize: 0.1ml | 410.12 USD
bs-12077R-Cy3 | GABRD/GABA A Receptor delta Antibody, Cy3 Conjugatedsize: 0.1ml | 431.06 USD
bs-12077R-Cy5 | GABRD/GABA A Receptor delta Antibody, Cy5 Conjugatedsize: 0.1ml | 431.06 USD
bs-12077R-Cy5.5 | GABRD/GABA A Receptor delta Antibody, Cy5.5 Conjugatedsize: 0.1ml | 431.06 USD
- Catalog numberbs-12077R-Cy5.5
- Price431.06 USD
- Long nameGABRD/GABA A Receptor delta Antibody, Cy5.5 Conjugated
- Tested applicationsFCM, IF(IHC-P)
- Recommended dilutionsFCM(1:20-100), IF(IHC-P)(1:50-200)
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation Emission675nm/694nm
- PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
- Additional conjugationCy5.5, Cy5.5
- ConjugatedThese antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.
- DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
- French translationanticorps
- Gene target
- Short nameGABRD/GABA A Receptor delta Antibody, Conjugated
- TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
- Alternative nameGABRD/GABA A Receptor delta (Antibody to), cyanine 5.5 coupled
1. Gene info
- Long gene namegamma-aminobutyric acid type A receptor delta subunit
- Synonyms gene name
- gamma-aminobutyric acid (GABA) A receptor, delta
- Synonyms name
- GenBank acession
- Discovery year1991-08-06
- Entrez gene record
- Pubmed identfication
- RefSeq identity
- Gamma-aminobutyric acid type A receptor subunits
- Havana BLAST/BLAT
- ConceptScope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
- PubMedData suggest that GABA(A) receptor subunits (alpha-1 and beta-3) are able to form homologous receptors with either delta (extrasynaptic) or gamma-2 subunits (synaptic); allosteric modulation appears similar in the presence of agonist etomidate.Data indicate that slow outward currents in thalamocortical neurons arise from astrocytic GABA release, and are mediated by delta-subunit-containing GABA(A) receptors.conclude that receptors can accumulate in slowly equilibrating desensitized states during repetitive receptor activation; results may indicate role for slow phases of desensitization for synaptic function under conditions of repeated receptor activationGluR1 protein was significantly decreased in hippocampi of controlled cortical impact and post-traumatic epilepsy groups, moreso in the latter.Increased expression of GABA(A) receptor beta 1 subunit in the interneurones of the periaqueductal gray matter could render the panic circuitry abnormally excitable by disinhibiting ongoing GABAergic inhibition.falling progesterone levels may be associated with expression of new receptors of the alpha4beta1delta subtype in periaqueductal grayChronic exposure to and withdrawal of progesterone induce differential effects on both expression of the delta subunit of GABA(A) receptors.alpha6-beta2-delta GABA A receptors exist in high/low affinity states and expression of subunits alters equilibrium between the two states.Internalization of the GABA(A) receptor delta subunit has not been studied in the past. These results suggest that rate of intracellular accumulation of the delta subunit was distinct and modulated by BDNF
- Gene ontology - Biological process
- Gene ontology - Cellular component
- Gene ontology - Molecular function
- Entrez Gene
bs-12077R-Cy7 | GABRD/GABA A Receptor delta Antibody, Cy7 Conjugatedsize: 0.1ml | 431.06 USD
bs-12077R-FITC | GABRD/GABA A Receptor delta Antibody, FITC Conjugatedsize: 0.1ml | 410.12 USD
bs-12077R-HRP | GABRD/GABA A Receptor delta Antibody, HRP Conjugatedsize: 0.1ml | 431.06 USD
bs-12077R-PE | GABRD/GABA A Receptor delta Antibody, PE Conjugatedsize: 0.1ml | 453.23 USD
MART-1, ID (MLANA, MART1, Melanoma antigen recognized by T-cells 1, Antigen LB39-AA, Antigen SK29-AA, Protein Melan-A) Antibody
Supplier:Bioss Primary Conjugated Antibodies. ALEXA FLUOR
Supplier:Bioss Primary Conjugated Antibodies
Supplier:Bioss Primary Unconjugated Antibodies