FRK, Active

• Catalog number
  7765-5
• Price
  Please ask
• Size
  5 ug

• Synonyms
  FRK, fyn-related kinase
• Alternative_names
  FRK, fyn-related kinase, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5
• Description
  Functions during G1 and S phase of the cell cycle and suppresses growth
• Recombinant
  Yes
• Source
  Baculovirus (Sf9 insect cells)
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Activity Specifications test method
  The specific activity of FRK was determined to be 997 nmol /min/mg as per activity assay protocol.
• Molecular Weight
  60.0 kDa
• Storage Temp
  -80°C
• Shipping
  dry ice
• Shelf Life
  12 months
• Concentration
  0.1mg/ml
• Appearance
  Liquid
• Physical form description
  Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Background Information
  FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo (1). Overexpression of FRK in β-cells from the pancreas increases the susceptibility of these cells to β-cell-toxic events (hallmark of Type I diabetes)(2).
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet

• Gene target
  FRK   Active  
• Gene symbol
  FRK
• Short name
  FRK, Active
• Alternative name
  FYN oncogene related to v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian), FGR, YES-related kinase, functionnal
• Alternative to gene target
  fyn-related kinase, GTK and PTK5 and RAK, FRK and IDBG-95607 and ENSG00000111816 and 2444, transferase activity, nuclei, Frk and IDBG-143883 and ENSMUSG00000019779 and 14302, FRK and IDBG-631180 and ENSBTAG00000020018 and 509227

Gene info

• Identity
  HGNC:3955
• Gene
  FRK
• Long gene name
  fyn related Src family tyrosine kinase
• Synonyms gene
  • PTK5
• Synonyms gene name
  • PTK5 protein tyrosine kinase 5
  • fyn-related kinase
  • fyn-related Src family tyrosine kinase
• Synonyms
  • RAK
  • GTK
• GenBank acession
  • U00803
• Locus
  6q22.1
• Discovery year
  1995-02-08
• Entrez gene record
  2444
• Pubmed identfication
  • 7510261
• RefSeq identity
  • NM_002031
• Classification
  • Src family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000015424

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