FOXA2/HNF 3beta Antibody
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Catalog numberbs-2358R
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PricePlease ask
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Size0.1ml
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Long nameFOXA2/HNF 3beta Primary Polyclonal Antibody
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Also known asFOXA2/HNF 3beta PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenFOXA2/HNF 3beta
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SpecificityThis is a highly specific antibody against FOXA2/HNF 3beta.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range200-250/457
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Subcellular locationCytoplasm, Nucleus
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HNF 3 beta
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Gene ID number3170
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Swiss ProtQ9Y261
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Tested ApplicationsWB, FCM, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenTranscription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesHNF3B; TCF3B; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Forkhead box protein A2; Transcription factor 3B; TCF-3B; FOXA2
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolFOXA2, ONECUT1, FOXM1
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Short nameAnti-FOXA2/HNF 3beta
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameFOXA2/HNF 3beta Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targetforkhead box A2, HNF3B and TCF3B, FOXA2 and IDBG-59234 and ENSG00000125798 and 3170, transcription regulatory region DNA binding, nuclei, Foxa2 and IDBG-208945 and ENSMUSG00000037025 and 15376, FOXA2 and IDBG-648756 and ENSBTAG00000012407 and 503580
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Gene info
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Identity
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Gene
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Long gene nameforkhead box A2
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Synonyms gene
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Synonyms gene name
- hepatocyte nuclear factor 3, beta
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GenBank acession
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Locus
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Discovery year1998-02-11
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Entrez gene record
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Pubmed identfication
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Classification
- Forkhead boxes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameone cut homeobox 1
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Synonyms gene
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Synonyms gene name
- one cut domain, family member 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-02-11
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Entrez gene record
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Pubmed identfication
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Classification
- CUT class homeoboxes and pseudogenes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameforkhead box M1
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-07-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Forkhead boxes
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data