FLI 06 for cell activation

FLI 06 for cell activation is available 2 times from Biovision labs

2603-5 | FLI-06 for cell activationsize: 5 mg | 217.06 USD

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2603-25 | FLI-06 for cell activationsize: 25 mg | 673.36 USD

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  • Description
    A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other known secretion inhibitors. FLI-06 blocks secretion by inhibiting the recruitment of cargo to ER exit sites, but not the formation of COPII vesicles. FLI-06 transforms the tubular regions of the ER to large sheets, suggesting that regions of high curvature at ER exit sites are essential for the recruitment of cargo.
  • Peptide sequence
    N/A
  • CAS number
    313967-18-9
  • Molecular weight
    438.52
  • Category
    Biochemicals
  • Other name
    Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
  • Molecular formula
    C₂₅H₃₀N₂O₅
  • Physical appearance
    Yellow solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    >98% by HPLC
  • Reconstitute instructions
    DMSO (~40 mg/ml) or EtOH (~ 8 mg/ml)
  • Storage condition
    -20 ̊C
  • Shipping condition
    Gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and light
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    FLI-06 for activation
  • Technique
    activation
  • Alternative name
    FLI-06 to measure cellular activation
  • Tissue
    cell
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