FGFR1 (1440CT772.50.23) Monoclonal Antibody

• Catalog number
  bsm-51288M
• Price
  Please ask
• Size
  0.1ml

• Long name
  FGFR1 (1440CT772.50.23) Monoclonal Antibody
• Also known as
  FGFR1 (1440CT772.50.23) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  FGFR1
• Specificity
  This is a highly specific antibody against FGFR1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  1440CT772.50.23
• Source
  This FGFR1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 806-842 amino acids from the C-terminal region of human FGFR1.
• Gene ID number
  2260
• Swiss Prot
  P11362
• Tested Applications
  WB, IHC-P, IF
• Recommended dilutions
  IHC-P(1:25), IF(1:25),WB(1:2000)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; Fms-like tyrosine kinase 2; Proto-oncogene c-Fgr; FGFR1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  FGFR1   1440CT772   Monoclonal  
• Gene symbol
  FGFR1
• Short name
  Anti-FGFR1
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)1 κ
• Alternative name
  FGFR1 (1440CT772.50.23) Monoclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  fibroblast growth factor receptor 1, bFGF-R-1 and BFGFR and CD331 and CEK and FGFBR and FGFR-1 and FLG and FLT-2 and FLT2 and HBGFR and HH2 and HRTFDS and KAL2 and N-SAM and OGD, FGFR1 and IDBG-17796 and ENSG00000077782 and 2260, transferase activity, nuclei, Fgfr1 and IDBG-143767 and ENSMUSG00000031565 and 14182, FGFR1 and IDBG-629273 and ENSBTAG00000015457 and 281768

Gene info

• Identity
  HGNC:3688
• Gene
  FGFR1
• Long gene name
  fibroblast growth factor receptor 1
• Synonyms gene
  • FLT2
  • KAL2
• Synonyms gene name
  • fms-related tyrosine kinase 2
• Synonyms
  • H2
  • H3
  • H4
  • H5
  • CEK
  • FLG
  • BFGFR
  • N-SAM
  • CD331
• Synonyms name
  • Pfeiffer syndrome
• GenBank acession
  • M34185
• Locus
  8p11.23
• Discovery year
  1992-02-25
• Entrez gene record
  2260
• Pubmed identfication
  • 2162671
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000147366
• Locus Specific Databases
  • LRG_993

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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