FANCA Antibody

• Catalog number
  bs-13138R
• Price
  Please ask
• Size
  0.1ml

• Long name
  FANCA Primary Polyclonal Antibody
• Also known as
  FANCA PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  FANCA
• Specificity
  This is a highly specific antibody against FANCA.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FANCA
• Gene ID number
  2175
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least eight complementation groups (A-G) have been identified and six FA genes (for subtypes A, C, D2, E, F and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF alpha signaling. Phosphorylation of FANC (Fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway. FANCA, also known as FACA and FANCH, associates with the Brm-related gene 1 (BRG1) product, a subunit of the SWI/SNF complex which remodels chromatin structure through a DNA-dependent ATPase activity. FANCA is mainly expressed in lymphoid tissues, testis and ovary. The amino-terminal region of the FANCA protein is required for FANCG binding, FANCC binding, nuclear localization and functional activity of the complex. The human FANCA gene maps to chromosome 16q24.3 and encodes a 1,455 amino acid protein.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  FA 1; FA; FA H; FA1; FAA; FACA; FAH; Fanca; FANCA_HUMAN; FANCH; Fanconi anemia complementation group A; Fanconi anemia complementation group H; Fanconi anemia group A protein; Fanconi anemia type 1; MGC75158; Protein FACA.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FANCA  
• Gene symbol
  FANCA
• Short name
  Anti-FANCA
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  FANCA Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  Fanconi anemia, complementation group A, FA and FA-H and FA1 and FAA and FACA and FAH and FANCH, FANCA and IDBG-48213 and ENSG00000187741 and 2175, protein binding, nuclei, Fanca and IDBG-198733 and ENSMUSG00000032815 and 14087, FANCA and IDBG-630970 and ENSBTAG00000001906 and

Gene info

• Identity
  HGNC:3582
• Gene
  FANCA
• Long gene name
  FA complementation group A
• Synonyms gene
  • FACA
  • FANCH
• Synonyms gene name
  • Fanconi anemia complementation group A
• Synonyms
  • FAA
  • FA-H
  • FAH
• GenBank acession
  • Z83067
• Locus
  16q24.3
• Discovery year
  1995-12-22
• Entrez gene record
  2175
• Pubmed identfication
  • 7581462
  • 9382107
• Classification
  • FA complementation groups
  • FA core complex
• VEGA ID
  OTTHUMG00000173049
• Locus Specific Databases
  • Fanconi Anaemia Mutation Database
  • Global Variome shared LOVD
  • LRG_495

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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