Mouse Anti-Human FADD-SEPH

• Catalog number
  GEN670128
• Price
  Please ask
• Size
  50 Tests

• Also known as
  FADD
• Other names
  FADD; N/A; protein FADD; N/A; N/A
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  fadd; N/A; N/A; N/A
• Gene name synonims
  fadd; N/A; N/A; N/A
• Other gene names
  fadd; N/A; N/A; N/A
• Clonality
  Monoclonal
• Immunoglobulin isotype
  Mouse IgG1
• Clone
  1A11
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  Human FADD Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1 beta -converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.1-6; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  Sepharose 4B (SEPH) Conjugate
• Concentration
  N/A
• Storage and shipping
  The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. The Sepharose 4B (SEPH) conjugate is supplied as 50 tests in 2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store the antibody ats should be kept in the range of 1-7 degrees Celsius.. Shake well before use. Reagents are stable for the period shown on the label if stored as directed.
• Tested applications
  ELISA; Immunoprecipitation; Western Blot
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Test
  MBS Monoclonals supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Latin name
  Mus musculus

• Gene target
  FADD-SEPH  
• Gene symbol
  FADD
• Short name
  Mouse Anti- FADD-SEPH
• Technique
  anti-Human, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, mouses
• Host
  mouse
• Species
  Human, Humans, Mouses
• Alternative name
  Anti-Mouse Anti-Human FADD-SEPH
• Alternative technique
  murine, antibodies
• Alternative to gene target
  Fas (TNFRSF6)-associated via death domain, MORT1, FADD and IDBG-62144 and ENSG00000168040 and 8772, identical protein binding, Plasma membranes, Fadd and IDBG-212910 and ENSMUSG00000031077 and 14082, FADD and IDBG-645056 and ENSBTAG00000018274 and 493720

Gene info

• Identity
  HGNC:3573
• Gene
  FADD
• Long gene name
  Fas associated via death domain
• Synonyms gene name
  • Fas (TNFRSF6)-associated via death domain
• Synonyms
  • MORT1
  • GIG3
• Synonyms name
  • Fas-associating protein with death domain
  • Fas-associating death domain-containing protein
  • mediator of receptor-induced toxicity
  • growth-inhibiting gene 3 protein
• GenBank acession
  • U24231
• Locus
  11q13.3
• Discovery year
  1999-05-07
• Entrez gene record
  8772
• Pubmed identfication
  • 7536190
  • 7538907
• RefSeq identity
  • NM_003824
• Classification
  • Death effector domain containing
  • Death inducing signaling complex
  • Ripoptosome
• VEGA ID
  OTTHUMG00000167264
• Locus Specific Databases
  • LRG_228

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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