EZSolution™ Torcetrapib

  • Catalog number
    2533-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    (2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; CP-529414, CP529414, CP 529414
  • Description
    Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels. However, in clinical trials, Torcetrapib displayed unfavorable off-target effects in cardiovascular system. PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.
  • CAS Number
    262352-17-0
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₆H₂₅F₉N₂O₄
  • Molecular Weight
    600.47
  • Cell Permeable
    Yes
  • Purity
    ≥98%
  • Handling
    Protect from light and moisture
  • Tag Line
    A CETP inhibitor
  • Storage Condition
    -20 ̊C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • PubChem CID
    159325
  • SMILES
    CCC1CC(C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)OC
  • InChi
    InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
  • InChi Key
    CMSGWTNRGKRWGS-NQIIRXRSSA-N
  • MSDS Available
    Yes
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