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Alternative_name
(2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; CP-529414, CP529414, CP 529414
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Description
Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels. However, in clinical trials, Torcetrapib displayed unfavorable off-target effects in cardiovascular system. PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.
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CAS Number
262352-17-0
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₆H₂₅F₉N₂O₄
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Molecular Weight
600.47
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Cell Permeable
Yes
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Purity
≥98%
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Handling
Protect from light and moisture
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Tag Line
A CETP inhibitor
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Storage Condition
-20 ̊C
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Shipping Condition
gel pack
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Shelf Life
12 months
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PubChem CID
159325
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SMILES
CCC1CC(C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)OC
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InChi
InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
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InChi Key
CMSGWTNRGKRWGS-NQIIRXRSSA-N
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MSDS Available
Yes