EZSolution™ Stat3 Inhibitor I, S3I-201
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Catalog number
2541-5
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Price
Please ask
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Size
5 mg
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Alternative_name
2-Hydroxy-4-[[[[4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid; NSC 74859; S3I-201
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Description
Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC₅₀ = 86 ± 33 µM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo.
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CAS Number
501919-59-1
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₆H₁₅NO₇S
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Molecular Weight
365.36
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Cell Permeable
Yes
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Purity
≥97% by HPLC
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Handling
Protect from air and moisture
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Tag Line
A Stat3 Inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
12months
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MDL Number
MFCD09907564
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PubChem CID
252682
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SMILES
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
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InChi
InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
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InChi Key
HWNUSGNZBAISFM-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
OR3A3
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Short name
EZSolution™ Stat3 Inhibitor I, S3I-201
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Alternative name
EZSolution™ signal transducer and activator on transcription 3 (acute-phase response factor) suppressor I, S3I-201
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Alternative to gene target
signal transducer and activator of transcription 3 (acute-phase response factor), ADMIO and APRF and HIES, STAT3 and IDBG-50702 and ENSG00000168610 and 6774, protein dimerization activity, nuclei, Stat3 and IDBG-211637 and ENSMUSG00000004040 and 20848, STAT3 and IDBG-640197 and ENSBTAG00000021523 and 101910056,508541
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Gene info
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