Recombinant Mouse PTPN6 Protein (aa 207-597, His & GST tag)

  • Catalog number
    PKSM040450-20µg
  • Price
    Please ask
  • Size
    20µg
  • Synonym
    70Z-SHP;hcp;Hcph;me;Ptp1C;PTPTY-42;SH-PTP1;SHP-1
  • Activity
    Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 4 μmoles/min/μg.
  • Sequence
    Ala207-Lys597
  • Fusion tag
    N-His & GST
  • Accession
    P29351-2
  • Expressed Host
    Baculovirus-Insect Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Endotoxin
    < 1.0 EU per μg of the protein as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    72.7 kDa
  • AP Mol Mass
    63 kDa
  • Formulation
    Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.0, 10% glycerol
  • Background
    PTPN6 is an enzyme which belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. It has been shown that PTPN6 interacts with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
  • Conjugation
    histidine
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    PTPN6   Protein   207-597   His   GST   tag  
  • Gene symbol
    MGST3, MIR597, PTPN6
  • Short name
    Recombinant Mouse PTPN6 Protein (aa 207-597, His & GST tag)
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Host
    mouse
  • Label
    His
  • Species
    Mouse, Mouses
  • Alternative name
    Rec. Mouse protein tyrosine phosphatase, non-receptor classification 6 Protein (aa 207-597, histidine & GST detection labelled)
  • Alternative technique
    rec, murine
  • Alternative to gene target
    protein tyrosine phosphatase, non-receptor type 6, HCP and HCPH and HPTP1C and PTP-1C and SH-PTP1 and SHP-1 and SHP-1L and SHP1, PTPN6 and IDBG-15719 and ENSG00000111679 and 5777, SH2 domain binding, nuclei, Ptpn6 and IDBG-187635 and ENSMUSG00000004266 and 15170, PTPN6 and IDBG-640141 and ENSBTAG00000020294 and 512312
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
Filters
Contact
Chat with gentaur.com employee