EZCyp™ Active Human Cytochrome P450 2C19

  • Catalog number
    7874-10
  • Price
    Please ask
  • Size
    10 mg
  • Synonyms
    Cytochrome P450 2C, Cytochrome P450 2C19, Cyt2C19, CYPIIC, CYPIIC19, Cyp2c, Microsomal cytochrome P450 2C19, active CYP2C19, human cyp2c19, human CYP2C19, CPCJ, recombinant CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19
  • Alternative_names
    Cytochrome P450 2C, Cytochrome P450 2C19, Cyt2C19, CYPIIC, CYPIIC19, Cyp2c, Microsomal cytochrome P450 2C19, active CYP2C19, human cyp2c19, human CYP2C19, CPCJ, recombinant CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19
  • Description
    Unique, cost-effective CYP2C19 catalytic system with active recombinant human CYP2C19 coexpressed with the active NADPH reductase in a semipermeable membrane system.
  • Recombinant
    Yes
  • Source
    Pichia pastoris
  • Purity
    NA
  • Endotoxin Level
    NA
  • Activity Specifications test method
    BioVision K848, Metabolite HPLC
  • Biological activity
    NA
  • Results
    NA
  • Binding Capacity
    NA
  • Unit Definition
    NA
  • Molecular Weight
    55 Kda
  • Storage Temp
    -20°C
  • Shipping
    gel pack
  • Shelf Life
    12 months
  • Appearance
    Dry powder
  • Physical form description
    Lyophilized powder
  • Reconstitution Instructions
    50 mM Potassium Phosphate buffer, pH 7.7
  • Background Information
    Cytochrome P450 2C19 (CYP2C19, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP2C19 is primarily expressed in liver and intestinal tissue and catalyzes oxidation of neutral or weakly basic lipophilic molecules with 2-3 hydrogen bond donor/acceptor sites. Isoforms of the CYP2C subfamily are responsible for metabolism of nearly 20% of all small molecule drugs commonly used by humans. Polymorphisms in the human CYP2C19 gene have been implicated in clinical drug/drug interactions involving widely-prescribed drugs, including proton pump inhibitors, antiplatelet agents and anticonvulsants. BioVision’s EZCypTM 2C19 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2C19 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Gene target
  • Gene symbol
    CYP3A7, CYP24A1, CYP1A1, CYP51A1, CYP2D6
  • Short name
    EZCyp™ Active Cytochrome P450 2C19
  • Species
    Humans
  • Alternative name
    EZCyp™ functionnal H. sapiens Cytochrome P450 2C19
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    cytochrome P450 family 24 subfamily A member 1
  • Synonyms gene
  • Synonyms gene name
    • cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)
    • cytochrome P450, family 24, subfamily A, polypeptide 1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1992-09-09
  • Entrez gene record
  • Classification
    • Cytochrome P450 family 24
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    cytochrome P450 family 51 subfamily A member 1
  • Synonyms gene
  • Synonyms gene name
    • cytochrome P450, 51 (lanosterol 14-alpha-demethylase)
    • cytochrome P450, family 51, subfamily A, polypeptide 1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1996-10-26
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Cytochrome P450 family 51
  • VEGA ID
Gene info
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