Exodus-2, Mouse Recombinant

• Catalog number
  7681-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  C-C motif chemokine 21, 6Ckine, Beta-chemokine exodus-2, Secondary lymphoid-tissue chemokine, SLC, Small-inducible cytokine A21
• Alternative_names
  C-C motif chemokine 21, 6Ckine, Beta-chemokine exodus-2, Secondary lymphoid-tissue chemokine, SLC, Small-inducible cytokine A21
• Description
  A chemokine which inhibits hemopoiesis and stimulates chemotaxis
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Endotoxin Level
  ≤ 1 EU/ug protein
• Biological activity
  The activity is determined by its ability to chemoattract 5-10 day old cultures of human peripheral blood lymphocytes at concentrations between 200 ng/mL- 600 ng/mL.
• Results
  200 ng/mL- 600 ng/mL.
• Molecular Weight
  12 kDa
• Storage Temp
  -20°C
• Shipping
  gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized powder
• Physical form description
  Lyophilized powder. Recommended reconstitution in sterile water at a concentration of 0.1 mg/mL
• Reconstitution Instructions
  Recommended reconstitution in sterile water at a concentration of 0.1 mg/mL
• Background Information
  Exodus-2, also known as CCL21 and 6Ckine, is a novel chemokine produced at high levels in human lymph node tissue and the spleen. 6Ckine signals through the CCR7 receptor to recruit thymocytes and activated T cells in vitro, but is not known to be chemotactic for monocytes. Human and mouse Exodus-2 share > 85% amino acid homology. Recombinant mouse Exodus-2 is a nonglycosylated protein, containing 110 amino acids, with a molecular weight of 12 kDa.
• Amino acid sequence
  SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FSPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Exodus-2  
• Gene symbol
  CCL21
• Short name
  Exodus-2, Mouse Recombinant
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Exodus-2, Mouse Rec.
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:10620
• Gene
  CCL21
• Long gene name
  C-C motif chemokine ligand 21
• Synonyms gene
  • SCYA21
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 21
  • chemokine (C-C motif) ligand 21
• Synonyms
  • SLC
  • exodus-2
  • TCA4
  • CKb9
  • 6Ckine
  • ECL
• Synonyms name
  • beta chemokine exodus-2
  • secondary lymphoid tissue chemokine
  • Efficient Chemoattractant for Lymphocytes
• GenBank acession
  • AB002409
• Locus
  9p13.3
• Discovery year
  1997-04-10
• Entrez gene record
  6366
• Pubmed identfication
  • 9235955
• RefSeq identity
  • NM_002989
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000019838

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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