Human CellExp™ LIFR /CD118, human recombinant

  • Catalog number
    7444-100
  • Price
    Please ask
  • Size
    100 ug
  • Synonyms
    LIFR, CD118, FLJ98106, FLJ99923, LIF-R, SJS2, STWS, SWS, Leukemia inhibitory factor receptor, Cluster of Differentiation 118
  • Alternative_names
    LIFR, CD118, FLJ98106, FLJ99923, LIF-R, SJS2, STWS, SWS, Leukemia inhibitory factor receptor, Cluster of Differentiation 118
  • Description
    A polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells
  • Recombinant
    Yes
  • Source
    HEK293 cells
  • Purity by SDS PAGE
    ≥96%
  • Assay
    SDS-PAGE
  • Biological activity
    Measured by its ability to inhibit LIF-dependent proliferation of TF1 human erythroleukemic cells. The ED50 for this effect is typically 5-10 ug/ml in the presence of 0.3 ng/ml of recombinant human LIF.
  • Results
    Measured by its ability to inhibit LIF-dependent proliferation of TF1 human erythroleukemic cells. The ED50 for this effect is typically 5-10 ug/ml in the presence of 0.3 ng/ml of recombinant human LIF.
  • Molecular Weight
    This protein is fused with the Fc region of human IgG1 at the CT. The reduced monomer has a calculated molecular mass of 115.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhLIFR-Fc monomer is approximately 135-150 kDa due to the glycosylation.
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.22 um filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
  • Reconstitution Instructions
    Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
  • Background Information
    Leukemia inhibitory factor receptor also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    CellExp™   LIFR   CD118  
  • Gene symbol
    LIFR, LIFR-AS1
  • Short name
    CellExp™ LIFR /CD118, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ leukemia inhibitory factor receptor alpha /CD118, H. sapiens Rec.
  • Alternative technique
    rec
  • Alternative to gene target
    leukemia inhibitory factor receptor alpha, CD118 and LIF-R and SJS2 and STWS and SWS, LIFR and IDBG-17489 and ENSG00000113594 and 3977, growth factor binding, Extracellular, Lifr and IDBG-128297 and ENSMUSG00000054263 and 16880, LIFR and IDBG-630017 and ENSBTAG00000010423 and 539504
Gene info
  • Identity
  • Gene
  • Long gene name
    LIF receptor subunit alpha
  • Synonyms gene name
    • leukemia inhibitory factor receptor
    • leukemia inhibitory factor receptor alpha
    • LIF receptor alpha
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1992-08-24
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Fibronectin type III domain containing
    • CD molecules
    • MicroRNA protein coding host genes
  • VEGA ID
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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