HER-2/NEU Antibody

  • Catalog number
    F46898-0.08ML
  • Price
    Please ask
  • Size
    0.08 ml
  • Category
    Antibody
  • Concentration
    In 1X PBS pH 7.4 with 0.09% sodium azide
  • Form
    Antigen affinity purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    HER-2/NEU
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Species reactivity
    Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB, ELISA
  • Recommended dilutions
    Western blot: 1:1000
  • Notes
    Titration of the HER-2/NEU antibody may be required due to differences in protocols and secondary/substrate sensitivity.
  • Intented use
    This HER-2/NEU antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    P04626
  • Purity
    Antigen affinity
  • Description
    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
  • Immunogen
    A portion of amino acids 1151-1179 from the human protein was used as the immunogen for this HER-2/NEU antibody.
  • Storage
    Aliquot the HER-2/NEU antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
  • Properties
    If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    ERBB2, NEU1, NEURL1, MIR7-2, MIR329-2, MIR512-2, MIR521-2, MIR1289-2, MIR509-2, KRTAP13-2
  • Short name
    Anti-HER-2/NEU
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit Ig
  • Alternative name
    Antibodies to HER-2/NEU
  • Alternative technique
    antibodies
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    neuraminidase 1
  • Synonyms gene
  • Synonyms gene name
    • sialidase 1 (lysosomal sialidase)
    • neuraminidase 1 (lysosomal sialidase)
  • GenBank acession
  • Locus
  • Discovery year
    2001-06-22
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Neuraminidases
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    neuralized E3 ubiquitin protein ligase 1
  • Synonyms gene
  • Synonyms gene name
    • neuralized (Drosophila)-like
    • neuralized-like (Drosophila)
    • neuralized homolog (Drosophila)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1999-02-09
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Ring finger proteins
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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