Erastin

• Catalog number
  2231-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
• Description
  Erastin is a selective antitumor agent that displays greater lethality in human tumour cells harbouring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling.
• CAS Number
  571203-78-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₃₁ClN₄O₄
• Molecular Weight
  547.04
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  An antitumor agent with RAS-selective lethality.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD09837984
• PubChem CID
  11214940
• PubChem CID Link
• SMILES
  CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
• InChi
  InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
• InChi Key
  BKQFRNYHFIQEKN-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Erastin  
• Short name
  Erastin
• Alternative name
  Erastin

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