EPO Receptor Tyr368 Antibody Conjugated
EPO Receptor Tyr368 Antibody Conjugated is available 7 times from Bioss primary conjugated antibodies labs
- CategoryConjugated Primary Antibodies
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenEPO Receptor Tyr368
- SpecificityThis is a highly specific antibody against EPO Receptor Tyr368.
- Modification siteTyr368
- ClonePolyclonal antibody
- Concentration1ug per 1ul
- SourceKLH conjugated synthetic phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr368
- Gene ID number2057
- CrossreactivityHuman, Mouse, Rat
- Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Antigen backgroundThe erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.
- Purification methodThis antibody was purified via Protein A.
- SynonymsEPO Receptor phospho Y368; p-EPO Receptor phospho Y368; EPOR phospho Y368; p-EPOR phospho Y368; erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.
- Gene target
- Alternative techniqueantibodies
- Alternative to gene targeterythropoietin, EP and MVCD2, EPO and IDBG-31941 and ENSG00000130427 and 2056, this GO :0001666 and response to hypoxia and biological process this GO :0005128 and erythropoietin receptor binding and molecular function this GO :0005179 and hormone activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007566 and embryo implantation and biological process this GO :0007568 and aging and biological process this GO :0007584 and response to nutrient and biological process this GO :0008015 and blood circulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009651 and response to salt stress and biological process this GO :0009986 and cell surface and cellular component this GO :0010523 and negative regulation of calcium ion transport into cytosol and biological process this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0030218 and erythrocyte differentiation and biological process this GO :0030295 and protein kinase activator activity and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033033 and negative regulation of myeloid cell apoptotic process and biological process this GO :0033189 and response to vitamin A and biological process this GO :0033574 and response to testosterone and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042541 and hemoglobin biosynthetic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043249 and erythrocyte maturation and biological process this GO :0043627 and response to estrogen and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046579 and positive regulation of Ras protein signal transduction and biological process this GO :0048678 and response to axon injury and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071474 and cellular hyperosmotic response and biological process this GO :1902219 and negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress and biological process this GO :1902251 and negative regulation of erythrocyte apoptotic process and biological process this GO :2001258 and negative regulation of cation channel activity and biological process, protein kinase activator activity, this GO :0005128: erythropoietin receptor binding and also this GO :0005179: hormone activity and also this GO :0005515: protein binding and also this GO :0030295: protein kinase activator activity, this GO :0005128: erythropoietin receptor binding, this GO :0005179: hormone activity, this GO :0005515: protein binding, this GO :0030295: protein kinase activator activity, Extracellular, Epo and IDBG-205003 and ENSMUSG00000029711 and 13856, EPO and IDBG-640493 and ENSBTAG00000003430 and 280784
bs-13087R-Biotin | EPO Receptor (Tyr368) Antibody, Biotin Conjugatedsize: 0.1ml | 430.54 USD
bs-13087R-Cy3 | EPO Receptor (Tyr368) Antibody, Cy3 Conjugatedsize: 0.1ml | 452.68 USD
bs-13087R-Cy5 | EPO Receptor (Tyr368) Antibody, Cy5 Conjugatedsize: 0.1ml | 452.68 USD
bs-13087R-Cy5.5 | EPO Receptor (Tyr368) Antibody, Cy5.5 Conjugatedsize: 0.1ml | 452.68 USD
bs-13087R-Cy7 | EPO Receptor (Tyr368) Antibody, Cy7 Conjugatedsize: 0.1ml | 452.68 USD
bs-13087R-FITC | EPO Receptor (Tyr368) Antibody, FITC Conjugatedsize: 0.1ml | 430.54 USD
- Catalog numberbs-13087R-FITC
- Price430.54 USD
- Long nameEPO Receptor (Tyr368) Antibody, FITC Conjugated
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation Emission494nm/518nm
- PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
- Additional conjugationAnti-FITC Antibody
- DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
- French translationanticorps
- Short nameEPO Receptor (Tyr368) Antibody, FITC Conjugated
- TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
- Alternative nameerythropoietin Receptor (Tyr368) (Antibody to), fluorecein coupled
1. Gene info
- Long gene nameerythropoietin
- GenBank acession
- Discovery year2001-06-22
- Entrez gene record
- Pubmed identfication
- RefSeq identity
- Endogenous ligands
- Havana BLAST/BLAT
- ConceptScope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
- PubMeda novel role for GATA-4 and TAL1 to affect skeletal myogenic differentiation and EPO response via cross-talk with Sirt1.investigated the mechanism of erythropoietin production by hypoxia in vitro using liver hepatocell (HepG2) cell lineSecreted MIR122 reached the kidney and reduced expression of erythropoietin, contributing to inflammation-induced anemia.findings reveal a novel function of LRRK2 in regulating EPO expression and imply a potentially novel relationship between PD genes and hematopoiesis.Data suggest that erythropoietin is one of the target genes of hypoxia-inducible factor-2 alpha responsible for experimental retinopathy of prematurity.findings show that simultaneous genetic inactivation of all three three prolyl hydroxylases (PHD1, PHD2, and PHD3) reactivates hepatic erythropoietin production and stimulates red blood synthesisThe observed alterations in the muscle transcriptome suggest that physiological concentrations of EPO exert both direct and indirect muscle-protecting effects during exercise.pharmacologic downstream inhibition of the Bmp-Smad pathway by dorsomorphin, which targets the BMP receptors, improves the hepcidin responsiveness to EPO in Tmprss6 KO mice.
- Gene ontology - Biological process
- Gene ontology - Cellular component
- Gene ontology - Molecular function
- Entrez Gene
bs-13087R-HRP | EPO Receptor (Tyr368) Antibody, HRP Conjugatedsize: 0.1ml | 452.68 USD