(-)-Epigallocatechin gallate

Alternative_name

EGCG; (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)
Description

A polyphenol flavonoid that displays antitumor and antioxidant properties. Inhibits telomerase and DNA methyltransferase (DNMT) and blocks the activation of EGF receptors and HER-2 receptors. Also potently and specifically inhibits chymotrypsin-like activity of the proteasome in vitro (IC₅₀= 86-194 nM) and in vivo (IC₅₀ =1 -10 µM).
CAS Number

989-51-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₁₈O₁₁
Molecular Weight

458.37
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO or EtOH
Handling

Protect from air and moisture
Tag Line

An antioxidant
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD00075940
PubChem CID

65064
PubChem CID Link
SMILES

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
InChi

InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
InChi Key

WMBWREPUVVBILR-WIYYLYMNSA-N
Data Sheet Link
MSDS Available

Yes