EPH receptor A4 Antibody Conjugated
EPH receptor A4 Antibody Conjugated is available 7 times from Bioss primary conjugated antibodies labs
- CategoryConjugated Primary Antibodies
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenEPH receptor A4
- SpecificityThis is a highly specific antibody against EPH receptor A4.
- Modification siteNone
- ClonePolyclonal antibody
- Concentration1ug per 1ul
- Subcellular locationCytoplasm
- SourceKLH conjugated synthetic peptide derived from human EphA4
- Gene ID number2043
- Swiss ProtP54764
- CrossreactivityHuman, Rat
- Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Antigen backgroundReceptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
- Purification methodThis antibody was purified via Protein A.
- SynonymsSEK; HEK8; TYRO1; Ephrin type-A receptor 4; EPH-like kinase 8; EK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK; EPHA4
- Gene target
- Alternative techniqueantibodies
bs-1764R-Biotin | EPH receptor A4 Antibody, Biotin Conjugatedsize: 0.1ml | 408.79 USD
bs-1764R-Cy3 | EPH receptor A4 Antibody, Cy3 Conjugatedsize: 0.1ml | 429.66 USD
- Catalog numberbs-1764R-Cy3
- Price429.66 USD
- Long nameEPH receptor A4 Polyclonal Antibody, Cy3 Conjugated
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation Emission512,550nm/570,615nm
- PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the EPH receptor A4 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
- Additional conjugationcy3 conjugation kit
- DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
- French translationanticorps
- Short nameEPH receptor A4 Antibody, Conjugated
- TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
- Alternative nameEPH receptor A4 (Antibody to), cyanine 3 coupled
1. Gene info
- Long gene nameEPH receptor A1
- Synonyms gene
- Synonyms gene name
- GenBank acession
- Discovery year1989-05-16
- Entrez gene record
- Pubmed identfication
- Sterile alpha motif domain containing
- Fibronectin type III domain containing
- EPH receptors
- Havana BLAST/BLAT
- ConceptScope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
- PubMedI 12 acquired a higher affinity toward EphA2 with K(d) 18 nm and inhibited vascular endothelial growth factor-dependent angiogenic invasion in a Matrigel plug assayEphA2 and EphrinA-1 may play an important role in the development of a subset of early cervical cancersResults suggest that EphA1-receptor transmembrane domains contribute to the dimerization-mediated receptor activation.Eph-A1 staining intensity was significantly associated with tumor size and tumor histopathological stage in pancreatic ductal adenocarcinomaThe EphA1 expression level is a potential prognostic marker in gastric carcinoma, and may provide a novel target of therapy for gastric carcinoma.Results show that EphA1 appears to be a differentiation marker for esophageal squamous cells, and its increased expression is positively associated with lymph node metastasis and advanced disease stage.
- Gene ontology - Biological process
- Gene ontology - Cellular component
- Gene ontology - Molecular function
- Entrez Gene
bs-1764R-Cy5 | EPH receptor A4 Antibody, Cy5 Conjugatedsize: 0.1ml | 429.66 USD
bs-1764R-Cy5.5 | EPH receptor A4 Antibody, Cy5.5 Conjugatedsize: 0.1ml | 429.66 USD
bs-1764R-Cy7 | EPH receptor A4 Antibody, Cy7 Conjugatedsize: 0.1ml | 429.66 USD
bs-1764R-FITC | EPH receptor A4 Antibody, FITC Conjugatedsize: 0.1ml | 408.79 USD
bs-1764R-HRP | EPH receptor A4 Antibody, HRP Conjugatedsize: 0.1ml | 429.66 USD