EPAC1 Recombinant Protein

• Catalog number
  95-116
• Price
  Please ask
• Size
  0.05 mg

• About recombinant protein
  EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is expressed most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal chord (1). Epac1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family (2). This activation of Rap influeces numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, Epac1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formatioon, intracellular Ca++ signalling, ion transporter activity, and exocytosis (reviewed in 3).
• Other name of the recombinant
  EPAC1 Antibody: EPAC, EPAC1, bcm910, HSU79275, CAMP-GEFI, CGEF1, EPAC, Rap guanine nucleotide exchange factor 3, Exchange factor directly activated by cAMP 1, EPAC 1
• Recombinant in
  E. coli
• His tag on the recombinant protein
  Fusion Partner: C-terminal His-tag
• SEQUENCE
  aa 58 - 181
• Activity
  not available
• Use of recmbinant
  This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
• Protein is used in
  E, WB, MS
• Suspention medium
  1X PBS containing 0.1% SDS
• Keep at
  Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  21450061
• Accession nr
  NP_659099
• KDa of reombinant
  19 kDa (Calculated)
• Pureity
  ~95%
• About
  Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
• Protein s origin
  Mouse
• Vial
  Liquid
• NCBI ID
  10411
• Gene name
  Rap guanine nucleotide exchange factor (GEF) 3
• Source
  Homo sapiens
• Uniprot
  O95398
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  EPAC1   Protein  
• Gene symbol
  RAPGEF3
• Short name
  EPAC1 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  EPAC1 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:16629
• Gene
  RAPGEF3
• Long gene name
  Rap guanine nucleotide exchange factor 3
• Synonyms gene name
  • RAP guanine-nucleotide-exchange factor (GEF) 3
  • Rap guanine nucleotide exchange factor (GEF) 3
• Synonyms
  • cAMP-GEFI
  • EPAC
  • bcm910
• Synonyms name
  • exchange protein directly activated by cAMP 1
• GenBank acession
  • AK092448
• Locus
  12q13.11
• Discovery year
  2004-03-01
• Entrez gene record
  10411
• Pubmed identfication
  • 10777494
  • 9856955
• RefSeq identity
  • NM_006105
• VEGA ID
  OTTHUMG00000133667

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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