Eotaxin/CCL11, human recombinant

• Catalog number
  4028-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  human Eotaxin
• Alternative_names
  Eotaxin, C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11
• Description
  A chemokine characterized by its high chemotactic selectivity for eosinophils
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥97%
• Assay
  SDS-PAGE
• Purity
  ≥97%
• Biological activity
  The ED₅₀ of human Eotaxin by chemotaxis based assays is 10 ng/ml using human peripheral blood eosinophils.
• Results
  10 ng/ ml
• Molecular Weight
  8.3 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized from 20 mM phosphate buffer (pH 7.4) and 150 mM NaCl.
• Reconstitution Instructions
  The lyophilized Eotaxin can be reconstituted in water to a concentration of 0.1-1 µg/µl. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.
• Background Information
  Eotaxin is a recently discovered chemokine characterized by its high chemotactic selectivity for eosinophils. The position of the four cystein residues in Eotaxin places it in the C-C family of chemokines, along with chemokines such as RANTES, MCP-3, and MIP-1 alpha. The human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues. The sequence of the first five N-terminal amino acids is Gly-Pro-Ala-Ser-Val.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Eotaxin/CCL11  
• Gene symbol
  CCL11
• Short name
  Eotaxin/CCL11, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Eotaxin/chemokine (C-C motif) ligand 11, H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  chemokine (C-C motif) ligand 11, SCYA11, CCL11 and IDBG-40645 and ENSG00000172156 and 6356, chemokine activity, Extracellular, Ccl11 and IDBG-204519 and ENSMUSG00000020676 and 20292, CCL11 and IDBG-630948 and ENSBTAG00000004129 and 404072

Gene info

• Identity
  HGNC:10610
• Gene
  CCL11
• Long gene name
  C-C motif chemokine ligand 11
• Synonyms gene
  • SCYA11
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
  • chemokine (C-C motif) ligand 11
• Synonyms
  • eotaxin
  • MGC22554
• Synonyms name
  • eotaxin-1
• GenBank acession
  • AB063614
• Locus
  17q12
• Discovery year
  1996-04-24
• Entrez gene record
  6356
• Pubmed identfication
  • 9169149
• RefSeq identity
  • NM_002986
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132884

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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