G-CSF
-
Catalog numberE21-002
-
PricePlease ask
-
Size10ug
-
-
Shipping_TemperatureAmbient
-
Product_StateLyophilized
-
Formulation_DescriptionLyophilized from a 0.2 μm filtered solution of 10mM HAc-NaAc, 150mM NaCl, 0.004% Tween 80, 5% Mannitol, pH 4.0.
-
StorageLyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
ReconstitutionAlways centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
-
PurityGreater than 95% as determined by reducing SDS-PAGE.
-
EndotoxinLess than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
-
BackgroundHuman Granulocyte-Colony-Stimulating Factor (G-CSF) is 20 kD glycoprotein containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and it functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The synthesis of G-CSF can be induced by bacterial endotoxins, TNF, Interleukin-1, and GM-CSF. Prostaglandin E2 inhibits the synthesis of G-CSF. In epithelial, endothelial, and fibroblastic cells secretion of G-CSF is induced by Interleukin-17.
-
Alternative NamesGranulocyte Colony-Stimulating Factor; G-CSF; Pluripoietin; Filgrastim; Lenograstim; CSF3; C17orf33; GCSF
-
Expression systemE.coli
-
GeneGranulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim.
-
Gene target
-
Gene symbolCSF3, IGHV3-71, HLA-G, NCAPG, CSF2, FOLR3, SNRPG, GNAO1, CSF1, SFTA2
-
Short nameG-CSF
-
SpeciesHuman
-
Alternative nameG-CSF
-
Gene info
-
Identity
-
Gene
-
Long gene namecolony stimulating factor 3
-
Synonyms gene
-
Synonyms gene name
- chromosome 17 open reading frame 33
- colony stimulating factor 3 (granulocyte)
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Receptor ligands
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin heavy variable 3-71 (pseudogene)
-
Synonyms gene
-
Synonyms gene name
- immunoglobulin heavy variable 3-71
- immunoglobulin heavy variable 3-G pseudogene (provisional)
- immunoglobulin heavy variable 3-G (provisional)
- immunoglobulin heavy variable 3-71 pseudogene
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2000-04-04
-
Entrez gene record
-
RefSeq identity
-
Classification
- Immunoglobulin heavy locus at 14q32.33
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemajor histocompatibility complex, class I, G
-
Synonyms gene name
- HLA-G histocompatibility antigen, class I, G
-
Synonyms name
-
Locus
-
Discovery year1990-09-10
-
Entrez gene record
-
RefSeq identity
-
Classification
- C1-set domain containing
- Histocompatibility complex
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namenon-SMC condensin I complex subunit G
-
Synonyms gene name
- non-SMC condensin I complex, subunit G
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2006-09-04
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Armadillo like helical domain containing
- Condensin I subunits
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namecolony stimulating factor 2
-
Synonyms gene name
- colony stimulating factor 2 (granulocyte-macrophage)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namefolate receptor gamma
-
Synonyms gene name
- folate receptor 3 (gamma)
- folate receptor 3
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1997-09-05
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesmall nuclear ribonucleoprotein polypeptide G
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1990-06-13
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Sm spliceosomal proteins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameG protein subunit alpha o1
-
Synonyms gene name
- guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
-
Synonyms
-
Locus
-
Discovery year1988-04-24
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- G protein subunits alpha, group i
- MicroRNA protein coding host genes
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namecolony stimulating factor 1
-
Synonyms gene name
- colony stimulating factor 1 (macrophage)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1986-01-01
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesurfactant associated 2
-
Synonyms gene
-
Synonyms gene name
- surfactant associated protein G
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2002-05-01
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID