DUB Inhibitor, PR-619

• Catalog number
  2302-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine
• Description
  A cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs). Treatment of cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.
• CAS Number
  2645-32-1
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₇H₅N₅S₂
• Molecular Weight
  223.28
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A deubiquitinylating enzymes (DUB) inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00830384
• SMILES
  N#CSC1=C(N)N=C(N)C(SC#N)=C1
• InChi
  InChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
• InChi Key
  ZXOBLNBVNROVLC-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  DUB   Inhibitor   PR-619  
• Gene symbol
  PRH2, TMEM37, PGR, MIR619, KMT5A, PRTN3
• Short name
  DUB Inhibitor, PR-619
• Alternative name
  DUB suppressor, PR-619

Gene info

• Identity
  HGNC:9367
• Gene
  PRH2
• Long gene name
  proline rich protein HaeIII subfamily 2
• Synonyms
  • Pr
• Synonyms name
  • parotid proline-rich protein
  • acidic salivary proline-rich protein, HaeIII type, 2
• Locus
  12p13.2
• Discovery year
  2001-06-22
• Entrez gene record
  5555
• Pubmed identfication
  • 3009472
• RefSeq identity
  • NM_001110213
• Classification
  • Proline rich proteins
• VEGA ID
  OTTHUMG00000168556

Gene info

• Identity
  HGNC:18216
• Gene
  TMEM37
• Long gene name
  transmembrane protein 37
• Synonyms
  • PR1
  • PR
• GenBank acession
  • AF361356
• Locus
  2q14.2
• Discovery year
  2004-12-14
• Entrez gene record
  140738
• RefSeq identity
  • NM_183240
• VEGA ID
  OTTHUMG00000153304

Gene info

• Identity
  HGNC:8910
• Gene
  PGR
• Long gene name
  progesterone receptor
• Synonyms
  • PR
  • NR3C3
• GenBank acession
  • M15716
• Locus
  11q22.1
• Discovery year
  2001-06-22
• Entrez gene record
  5241
• RefSeq identity
  • NM_000926
• Classification
  • Nuclear receptor subfamily 3 group C
• VEGA ID
  OTTHUMG00000167531

Gene info

• Identity
  HGNC:32875
• Gene
  MIR619
• Long gene name
  microRNA 619
• Synonyms gene
  • MIRN619
• Synonyms
  • hsa-mir-619
• Locus
  12q24.11
• Discovery year
  2006-05-17
• Entrez gene record
  693204
• RefSeq identity
  • NR_030350
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:29489
• Gene
  KMT5A
• Long gene name
  lysine methyltransferase 5A
• Synonyms gene
  • SETD8
• Synonyms gene name
  • SET domain containing (lysine methyltransferase) 8
  • lysine (K)-specific methyltransferase 5A
• Synonyms
  • SET8
  • SET07
  • PR-Set7
• GenBank acession
  • AY102937
• Locus
  12q24.31
• Discovery year
  2006-02-15
• Entrez gene record
  387893
• Pubmed identfication
  • 15933070
  • 12086618
  • 12121615
• RefSeq identity
  • NM_020382
• Classification
  • SET domain containing
  • Lysine methyltransferases
• VEGA ID
  OTTHUMG00000150477

Gene info

• Identity
  HGNC:9495
• Gene
  PRTN3
• Long gene name
  proteinase 3
• Synonyms
  • PR-3
  • ACPA
  • C-ANCA
  • AGP7
  • MBT
  • P29
• Synonyms name
  • myeloblastin
  • serine proteinase, neutrophil
  • Wegener granulomatosis autoantigen
• Locus
  19p13.3
• Discovery year
  1992-08-24
• Entrez gene record
  5657
• Pubmed identfication
  • 2258701
• RefSeq identity
  • NM_002777
• Classification
  • Granule associated serine proteases of immune defence
• VEGA ID
  OTTHUMG00000181838

Product images

Similar products