DPYD Antibody

• Catalog number
  bs-8288R
• Price
  Please ask
• Size
  0.1ml

• Long name
  DPYD Primary Polyclonal Antibody
• Also known as
  DPYD PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  DPYD
• Specificity
  This is a highly specific antibody against DPYD.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DPYD
• Gene ID number
  1806
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DHP; DHPDHase; Dihydropyrimidine dehydrogenase [NADP+]; Dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; DPYD; DPYD_HUMAN; MGC132008; MGC70799; OTTHUMP00000058954.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DPYD  
• Gene symbol
  DPYD-AS2, DPYD-AS1, DPYD-IT1, DPYD
• Short name
  Anti-DPYD
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  DPYD Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40196
• Gene
  DPYD-AS2
• Long gene name
  DPYD antisense RNA 2
• Synonyms gene name
  • DPYD antisense RNA 2 (non-protein coding)
• Locus
  1p21.3
• Discovery year
  2011-05-20
• Entrez gene record
  100873933
• Pubmed identfication
  • 28391028
• RefSeq identity
  • NR_046591
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000039680

Gene info

• Identity
  HGNC:40195
• Gene
  DPYD-AS1
• Long gene name
  DPYD antisense RNA 1
• Synonyms gene name
  • DPYD antisense RNA 1 (non-protein coding)
• Locus
  1p21.3
• Discovery year
  2011-05-20
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000039682

Gene info

• Identity
  HGNC:41326
• Gene
  DPYD-IT1
• Long gene name
  DPYD intronic transcript 1
• Synonyms gene name
  • DPYD intronic transcript 1 (non-protein coding)
• Locus
  1p21.3
• Discovery year
  2011-05-20
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000039679

Gene info

• Identity
  HGNC:3012
• Gene
  DPYD
• Long gene name
  dihydropyrimidine dehydrogenase
• Synonyms
  • DPD
  • DHPDHase
• Synonyms name
  • Dihydrothymine dehydrogenase
  • Dihydrouracil dehydrogenase
• GenBank acession
  • U20938
• Locus
  1p21.3
• Discovery year
  1994-07-07
• Entrez gene record
  1806
• Pubmed identfication
  • 7713523
• RefSeq identity
  • NM_000110
• VEGA ID
  OTTHUMG00000039683
• Locus Specific Databases
  • UMD Locus Specific Databases
  • LRG_722

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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