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Stock availabilitIn Stock
In Stock
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CAS number
866405-64-3
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Description
AMPK kinase inhibitor
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Molecular weight
399,5 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
AMPK Inhibitor, Compound C, 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C24H25N5O
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Origin
Synthetic
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Purity pourcentage
≥98% (HPLC)
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Soluble in
Soluble in DMSO (4 mg/ml, warm)
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Physical appearance
Yellow solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
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PubChem number
11524144
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Scientific context
Dorsomorphin is a potent and selective and reversible inhibitor of AMP-kinase, doing so in an ATP-competitive manner. It is also a selective inhibitor of Bone morphogenetic protein (BMP) signaling.
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Bibliography
1. Vucicevic L., et al. (2011) Autophagy 7(1): 40–50. 2. Yu P.B., et al. (2008). Nat. Chem. Biol. 4(1): 33–41.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Dorsomorphin (SIH-443), a AMPK kinase inhibitor. CAS #: 866405-64-3. Molecular Formula: C24H25N5O. Molecular Weight: 399.5 g/mol. Chemical structure of Dorsomorphin, a AMPK kinase inhibitor (SIH-443). CAS # 866405-64-3. Molecular Formula: C24H25N5O.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
