Doramapimod,p38 MAP kinase inhibitor

Research Area s

Cell Signaling , Cancer , Apoptosis , Cancer Growth Inhibitors , Tyrosine Kinase Inhibitors
Category

Small Molecules
Product Type

Inhibitor
CAS No

285983-48-4
MolecularFormula

C31H37N5O3
Molecular Weight

527.7
Purity

≥99% (HPLC)
Solubility

Soluble in DMSO
Appearance

White solid
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

Doramapimod p38 MAP kinase inhibitor
Gene symbol

MOAP1, MAP7, MASP2, MASP1
Short name

Doramapimod p38 MAP kinase inhibitor
Alternative name

Doramapimod,p38 mitogen-stimulated protein kinase phosphorylation catalyst suppressor

Identity

HGNC:6902
Gene

MASP2
Long gene name

MBL associated serine protease 2
Synonyms gene
- MASP1P1
Synonyms gene name
- mannan-binding lectin serine protease 2
- mannan-binding lectin serine peptidase 1 pseudogene 1
- mannan-binding lectin serine protease 1 pseudogene 1
Synonyms
- Map19
- sMAP
- MAP-2
Synonyms name
- mannose-binding lectin-associated serine protease 2
- mannose-binding lectin associated protein 19
GenBank acession
- X98400
Locus

1p36.22
Discovery year

1998-12-17
Entrez gene record

10747
Pubmed identfication
- 9087411
- 9777418
RefSeq identity
- NM_006610
Classification
- Sushi domain containing
- Complement system activation components
VEGA ID

OTTHUMG00000002121
Locus Specific Databases
- MASP2base: Mutation registry for MASP-2 deficiency
- LRG_82

Identity

HGNC:6901
Gene

MASP1
Long gene name

MBL associated serine protease 1
Synonyms gene
- CRARF
- PRSS5
Synonyms gene name
- mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor)
- mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
- mannan binding lectin serine peptidase 1
Synonyms
- MASP
- Map44
- MASP-3
- MAP-1
Synonyms name
- C4/C2 activating component of Ra-reactive factor
- mannose-binding lectin-associated serine protease 1
GenBank acession
- D28593
Locus

3q27.3
Discovery year

1995-07-06
Entrez gene record

5648
Pubmed identfication
- 8018603
- 8240317
RefSeq identity
- NM_001879
Classification
- Serine proteases
- Complement system activation components
- Sushi domain containing
VEGA ID

OTTHUMG00000156461
Locus Specific Databases
- LRG_349