DIAPH1 Antibody

• Catalog number
  bs-8256R
• Price
  Please ask
• Size
  0.1ml

• Long name
  DIAPH1 Primary Polyclonal Antibody
• Also known as
  DIAPH1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  DIAPH1
• Specificity
  This is a highly specific antibody against DIAPH1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DIAPH1
• Gene ID number
  1729
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DIAPH1; FLJ25265; Deafness autosomal dominant 1; deafness, autosomal dominant 1; DFNA1; DIAP1; DIAP1_HUMAN; DIAPH1; diaphanous homolog 1; Diaphanous protein homolog 1; Diaphanous related formin 1; Diaphanous-related formin-1; DRF1; hDIA1; LFHL1; low frequency hearing loss 1; p140DIA; Protein diaphanous homolog 1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DIAPH1  
• Gene symbol
  DIAPH1-AS1, DIAPH1
• Short name
  Anti-DIAPH1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  DIAPH1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40177
• Gene
  DIAPH1-AS1
• Long gene name
  DIAPH1 antisense RNA 1
• Locus
  5q31.3
• Discovery year
  2019-07-25
• Entrez gene record
  100505658
• RefSeq identity
  • NR_038333
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:2876
• Gene
  DIAPH1
• Long gene name
  diaphanous related formin 1
• Synonyms gene
  • DFNA1
• Synonyms gene name
  • diaphanous (Drosophila, homolog) 1
  • diaphanous homolog 1 (Drosophila)
• Synonyms
  • hDIA1
  • LFHL1
  • mDia1
• Synonyms name
  • mammalian diaphanous related formin 1
• GenBank acession
  • BC007411
• Locus
  5q31.3
• Discovery year
  1998-03-17
• Entrez gene record
  1729
• Pubmed identfication
  • 9360932
  • 1350680
• RefSeq identity
  • NM_005219
• Classification
  • Formins
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000149893
• Locus Specific Databases
  • Hereditary Hearing Loss Homepage
  • LRG_1117

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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