DFF45, Cleavage Site (Asp224) (ICAD, DNA Fragmentation Factor, Inhibitor of Caspase Activated Deoxyribonuclease)

• Catalog number
  MBS612126
• Price
  Please ask
• Size
  0.1 mL

• Products_type
  Antibody
• Products_short_name
  [DFF45, Cleavage Site]
• Products_name_syn
  [Anti -DFF45, Cleavage Site (Asp224) (ICAD, DNA Fragmentation Factor, Inhibitor of Caspase Activated Deoxyribonuclease)]
• Other_names
  [DNA fragmentation factor subunit alpha isoform 1; DNA fragmentation factor subunit alpha; DNA fragmentation factor subunit alpha; DFF45; inhibitor of CAD; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD]
• Other_gene_names
  [DFFA; DFFA; DFF1; ICAD; DFF-45; DFF1; DFF45; DFF-45; ICAD]
• Clonality
  Polyclonal
• Reactivity
  Human
• Specificity
  Cleaved DFF45 (Asp224) Antibody detects the carboxy-terminal fragment of DFF45 resulting from cleavage at Asp224. This antibody does not recognize full length DFF45 or other cleavage products of DFF45.
• Purity
  Affinity Purified Purified by Protein A affinity chromatography.
• Form
  Supplied as liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.
• Storage_stability
  May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  ELISA (EL/EIA), Western Blot (WB)
• Description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  DFF45   Cleavage   Site   Asp224   ICAD   DNA   Fragmentation   Factor   Inhibitor   Caspase   Activated   Deoxyribonuclease  
• Gene symbol
  DFFA, PRKDC, HLA-DOA
• Short name
  DFF45, Cleavage Site (Asp224) (ICAD, DNA Fragmentation Factor, Inhibitor of Caspase Activated Deoxyribonuclease)
• Technique
  dna
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  DFF45, Cleavage Site (Asp224) (ICAD, Desoxyribonucleic acid Fragmentation Factor, suppressor on caspase Activated Deoxyribonuclease)

Gene info

• Identity
  HGNC:2772
• Gene
  DFFA
• Long gene name
  DNA fragmentation factor subunit alpha
• Synonyms gene name
  • DNA fragmentation factor, 45 kD, alpha polypeptide
  • DNA fragmentation factor, 45kDa, alpha polypeptide
• Synonyms
  • DFF-45
  • DFF45
  • ICAD
  • DFF1
• Synonyms name
  • DNA fragmentation factor, 45 kD, alpha subunit
• GenBank acession
  • AF087573
• Locus
  1p36.22
• Discovery year
  1997-10-27
• Entrez gene record
  1676
• Pubmed identfication
  • 9605855
  • 9108473
• RefSeq identity
  • NM_004401
• VEGA ID
  OTTHUMG00000001909

Gene info

• Identity
  HGNC:9413
• Gene
  PRKDC
• Long gene name
  protein kinase, DNA-activated, catalytic subunit
• Synonyms gene
  • HYRC
  • HYRC1
• Synonyms gene name
  • protein kinase, DNA-activated, catalytic polypeptide
• Synonyms
  • DNPK1
  • p350
  • DNAPK
  • XRCC7
  • DNA-PKcs
  • DNAPKc
  • DNA-PKC
  • p460
• Synonyms name
  • DNA-dependent protein kinase catalytic subunit
• Locus
  8q11.21
• Discovery year
  1993-11-09
• Entrez gene record
  5591
• Pubmed identfication
  • 7638222
• RefSeq identity
  • NM_001081640
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000164239
• Locus Specific Databases
  • LRG_162

Gene info

• Identity
  HGNC:4936
• Gene
  HLA-DOA
• Long gene name
  major histocompatibility complex, class II, DO alpha
• Synonyms gene
  • HLA-DZA
  • HLA-DNA
• Synonyms
  • HLA-D0-alpha
• GenBank acession
  • M31525
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3111
• Pubmed identfication
  • 2370084
• RefSeq identity
  • NM_002119
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031211
• Locus Specific Databases
  • IMGT/HLA Database

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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