Dematin Antibody

• Catalog number
  bs-20187R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Dematin Primary Polyclonal Antibody
• Also known as
  Dematin PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Dematin
• Specificity
  This is a highly specific antibody against Dematin .
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  250-280/405
• Subcellular location
  Cytoplasm
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Dematin
• Gene ID number
  2039
• Swiss Prot
  Q08495
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DMT; EPB49; Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9; DMTN
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Dematin  
• Gene symbol
  DMTN
• Short name
  Anti-Dematin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Dematin Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3382
• Gene
  DMTN
• Long gene name
  dematin actin binding protein
• Synonyms gene
  • EPB49
• Synonyms gene name
  • erythrocyte membrane protein band 4.9 (dematin)
• Synonyms
  • DMT
• GenBank acession
  • U28389
• Locus
  8p21.3
• Discovery year
  1995-09-29
• Entrez gene record
  2039
• Pubmed identfication
  • 8341682
  • 12011427
• RefSeq identity
  • NM_001978
• VEGA ID
  OTTHUMG00000097087

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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