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Stock availabilitIn Stock
In Stock
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CAS number
522-17-8
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Description
Akt inhibitor
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Molecular weight
394,42 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
(7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one
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Product category
Small Molecules
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Product type
Inducer
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Chemical formula
C23H22O6
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 50 mM in ethanol and to 100 mM in DMSO
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Physical appearance
Cream Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
107935
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Scientific context
Deguelin is a rotenoid, and a naturally occurring insecticide. Deguelin displays anti-cancer activity by inhibiting the growth of pre-cancerous and cancerous cells (1). High doses may have negative effects on the heart, lungs and nerves however. Deguelin has also been shown to have a correlation with Parkinson’s disease in rats (2).
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Bibliography
1. Lee H.Y. (2004) Biochem Pharmacol. 68(6): 1119-1124. 2. Caboni P., et al. (2004) Chem Res. Toxicol. 17(11): 1540-1548.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Deguelin (SIH-251), a Akt inhibitor. CAS #: 522-17-8. Molecular Formula: C23H22O6. Molecular Weight: 394.42 g/mol. Chemical structure of Deguelin, a Akt inhibitor (SIH-251). CAS # 522-17-8. Molecular Formula: C23H22O6.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
