DDX58 (Ser8) Antibody
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Catalog numberbs-5299R
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PricePlease ask
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Size0.1ml
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Long nameDDX58 (Ser8) Primary Polyclonal Antibody
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Also known asDDX58 (Ser8) PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenDDX58 Ser8
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SpecificityThis is a highly specific antibody against DDX58 Ser8.
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Modification sPhosphorylation
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Modification site sSer8
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic phosphopeptide derived from human DDX58 around the phosphorylation site of Ser8
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Gene ID number23586
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenThe innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesDEAD/H Asp-Glu-Ala-Asp/His box polypeptide RIG-I; DKFZp434J1111; DKFZp686N19181; FLJ13599; C330021E21; OTTHUMP00000045225; DEAD Asp-Glu-Ala-Asp box polypeptide 58; DEAD Asp Glu Ala Asp/His box polypeptide; DEAD box protein 58; Probable ATP dependent RNA helicase DDX58; Retinoic acid inducible gene 1 protein; RIG I; rig-I; RIG1; rigi; RNA helicase.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolDDX58
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Short nameAnti-DDX58 Ser8
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameDDX58 (Ser8) Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targetDEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I and RIGI and RLR-1, DDX58 and IDBG-55854 and ENSG00000107201 and 23586, hydrolase activity, Cell surfaces, Ddx58 and IDBG-135957 and ENSMUSG00000040296 and 230073, DDX58 and IDBG-629773 and ENSBTAG00000003366 and 504760
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Gene info
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Identity
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Gene
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Long gene nameDExD/H-box helicase 58
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Synonyms gene name
- DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-05-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- DEAD-box helicases
- Caspase recruitment domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data