DDR2 Antibody (TYRO10)

  • Catalog number
    F50688-0.4ML
  • Price
    Please ask
  • Size
    0.4 ml
  • Category
    Antibody
  • Concentration
    In 1X PBS, pH 7.4, with 0.09% sodium azide
  • Form
    Purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    DDR2 (TYRO10)
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Species reactivity
    Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB, IHC, FACS, ELISA
  • Recommended dilutions
    Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50
  • Notes
    Titration of the DDR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
  • Intented use
    This DDR2 antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    Q16832
  • Purity
    Purified
  • Description
    DDR2/TYRO10 is a tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. [UniProt]
  • Immunogen
    This DDR2 antibody was produced from rabbits immunized with a his tag recombinant protein of human DDR2/TYRO10.
  • Storage
    Aliquot the DDR2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
  • Properties
    If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    DDR2   TYRO10  
  • Gene symbol
    DDR2
  • Short name
    Anti-DDR2 (TYRO10)
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit Ig
  • Alternative name
    Antibodies to DDR2 (TYRO10)
  • Alternative technique
    antibodies
  • Alternative to gene target
    discoidin domain receptor tyrosine kinase 2, MIG20a and NTRKR3 and TKT and TYRO10, DDR2 and IDBG-104396 and ENSG00000162733 and 4921, transferase activity, Plasma membranes, Ddr2 and IDBG-203608 and ENSMUSG00000026674 and 18214, BT.46641 and IDBG-629865 and ENSBTAG00000004885 and 533523
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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