DDR2 Antibody

• Catalog number
  PA1879
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  DDR2
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human Predicted to work with: mouse, rat
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of human DDR2(834-855aa RDTKNRPSFQEIHLLLLQQGDE), different from the related mouse sequence by three amino acids.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the DDR2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The DDR2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  DDR2(Discoidin domain receptor family, member 2) also known as NTRKR3 or TKT, is a human gene. Ddr2 protein was detected in most mouse tissues examined. Highest levels of phosphorylated Ddr2 were detected in lung, ovary, and skin, which did not correlate with Ddr2 protein levels. The DDR2 gene is mapped 1q23.3. Receptor tyrosine kinases(RTKs) play a key role in the communication of cells with their microenvironment.Using in situ hybridization with 1-week-old mice, Labrador et al.(2001) found that Ddr2 was expressed along chondrocyte columns in the proliferative region of the growth plate.Ddr2mRNA was also present, although dispersed, at areas of calcified cartilage in the cartilage-bone junction, as well as in the trabecular bone surface. Bargal et al.(2009) also identified a splice site mutation in the DDR2 gene, which resulted in the skipping of exon 17, in one of the Jewish families with SMED-SL originally reported by Borochowitz et al.(1993).
• Related articles
  1. Bargal, R., Cormier-Daire, V., Ben-Neriah, Z., Le Merrer, M., Sosna, J., Melki, J., Zangen, D. H., Smithson, S. F., Borochowitz, Z., Belostotsky, R., Raas-Rothschild, A.Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications. Am. J. Hum. Genet. 84: 80-84, 2009. 2. Borochowitz, Z., Langer, L. O., Jr., Gruber, H. E., Lachman, R., Katznelson, M. B.-M., Rimoin, D. L.Spondylo-meta-epiphyseal dysplasia (SMED), short limb-hand type: a congenital familial skeletal dysplasia with distinctive features and histopathology. Am. J. Med. Genet. 45: 320-326, 1993 3. Labrador, J. P., Azcoitia, V., Tuckermann, J., Lin, C., Olaso, E., Manes, S., Bruckner, K., Goergen, J.-L., Lemke, G., Yancopoulos, G., Angel, P., Martinez-A, C., Klein, R.The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO J. 2: 446-452, 2001.
• Gene Name
  DDR2
• Protein Name
  Discoidin domain-containing receptor 2
• Gene Full Name
  discoidin domain receptor tyrosine kinase 2
• Synonyms
  CD167 antigen-like family member B antibody|CD167b antibody|CD167b antigen antibody|Cell migration inducing protein 20 antibody|DDR 2 antibody|DDR2 antibody|DDR2_HUMAN antibody|Discoidin domain containing receptor 2 antibody|Discoidin domain receptor 2 antibody|Discoidin domain receptor family member 2 antibody|discoidin domain receptor tyrosine kinase 2 antibody|Discoidin domain-containing receptor 2 antibody|discoidin domain-containing receptor tyrosine kinase 2 antibody|Hydroxyaryl protein kinase antibody|MIG20a antibody|Migration inducing gene 16 protein antibody|Neurotrophic tyrosine kinase antibody|Neurotrophic tyrosine kinase receptor related 3 antibody|NTRKR 3 antibody|NTRKR3 antibody|Receptor protein tyrosine kinase TKT antibody|Receptor protein-tyrosine kinase TKT antibody|Receptor related 3 antibody|receptor-related 3 antibody|TKT antibody|TYRO 10 antibody|TYRO10 antibody|Tyrosine kinase receptor related to neurotrophic TRK antibody|Tyrosine protein kinase TYRO 10 antibody|Tyrosine protein kinase TYRO10 antibody|Tyrosine-protein kinase TYRO10 antibody|Tyrosylprotein kinase antibody
• Uniprot ID
  Q16832
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DDR2  
• Gene symbol
  DDR2
• Short name
  DDR2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  discoidin domain receptor tyrosine kinase 2 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  discoidin domain receptor tyrosine kinase 2, MIG20a and NTRKR3 and TKT and TYRO10, DDR2 and IDBG-104396 and ENSG00000162733 and 4921, transferase activity, Plasma membranes, Ddr2 and IDBG-203608 and ENSMUSG00000026674 and 18214, BT.46641 and IDBG-629865 and ENSBTAG00000004885 and 533523

Gene info

• Identity
  HGNC:2731
• Gene
  DDR2
• Long gene name
  discoidin domain receptor tyrosine kinase 2
• Synonyms gene
  • TYRO10
  • NTRKR3
• Synonyms gene name
  • discoidin domain receptor family, member 2
• Synonyms
  • TKT
• GenBank acession
  • AK095975
• Locus
  1q23.3
• Discovery year
  1999-06-17
• Entrez gene record
  4921
• Pubmed identfication
  • 9659899
• RefSeq identity
  • NM_006182
• Classification
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000034423
• Locus Specific Databases
  • LRG_1390

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products