DBeQ, p97 inhibitor

• Catalog number
  SIH-334-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  No Available. See included datasheet
• Description
  p97 inhibitor
• Molecular weight
  340,4 g/mol
• Primary research fields
  Cancer, Apoptosis
• Other name
  N,N'-Dibenzyl-2,4-quinazolinediamine, JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine, N2,N4-Bis(phenylmethyl)-2,4-quinazo­linediamine
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C22H20N4
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in 25 mg/ml DMSO
• Physical appearance
  Yellow Powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Toxic Material Causing other toxic effects- moderate eye irritant. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed Precautionary Statements: P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• PubChem number
  676352
• Scientific context
  A potent, selective and reversible inhibitor of the AAA-ATP p97 (ATPase associated with diverse cellular activities). Ki=3.2 M. It blocks ubiquitin-dependent protein clearance pathways. Cell permeable.
• Bibliography
  1. Chou T.F., et al. 2011 PNAS 108:4834.
• Release date
  6-Jun-2012
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of DBeQ (SIH-334), a p97 inhibitor. CAS #: N/A. Molecular Formula: C22H20N4. Molecular Weight: 340.4 g/mol. Chemical structure of DBeQ, a p97 inhibitor (SIH-334). CAS # N/A. Molecular Formula: C22H20N4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  DBeQ   p97   inhibitor  
• Short name
  DBeQ, p97 inhibitor
• Alternative name
  DBeQ, p97 suppressor

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