CYLD (1667CT857.3.6.1) Monoclonal Antibody

• Catalog number
  bsm-51375M
• Price
  Please ask
• Size
  0.1ml

• Long name
  CYLD (1667CT857.3.6.1) Monoclonal Antibody
• Also known as
  CYLD (1667CT857.3.6.1) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  CYLD
• Specificity
  This is a highly specific antibody against CYLD.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  1667CT857.3.6.1
• Source
  This CYLD antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 305-582 amino acids from human CYLD.
• Gene ID number
  1540
• Swiss Prot
  Q9NQC7
• Tested Applications
  WB, FCM
• Recommended dilutions
  FC(1:25), WB(1:4000),
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity).
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2; Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD; CYLD; KIAA0849; HSPC057
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CYLD   1667CT857   Monoclonal  
• Gene symbol
  CYLD-AS1, CYLD
• Short name
  Anti-CYLD
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)2a κ
• Alternative name
  CYLD (1667CT857.3.6.1) Monoclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:55352
• Gene
  CYLD-AS1
• Long gene name
  CYLD antisense RNA 1
• Locus
  16q12.1
• Discovery year
  2020-11-05
• Entrez gene record
  102724907
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:2584
• Gene
  CYLD
• Long gene name
  CYLD lysine 63 deubiquitinase
• Synonyms gene
  • CYLD1
• Synonyms gene name
  • cylindromatosis (turban tumor syndrome)
• Synonyms
  • KIAA0849
  • USPL2
• Synonyms name
  • ubiquitin specific peptidase like 2
• GenBank acession
  • AB020656
• Locus
  16q12.1
• Discovery year
  1996-12-17
• Entrez gene record
  1540
• Pubmed identfication
  • 7493027
• Classification
  • Ubiquitin specific peptidases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000173404
• Locus Specific Databases
  • LRG_491

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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